Ionic and Flutter are popular choices for cross-platform app development, but both have limitations, particularly in GUI flexibility and feature integration. Developers often face challenges when trying to create apps that work seamlessly across iOS and Android due to differing platform requirements. While Ionic is favored by some for its JavaScript support, others suggest React Native as a better alternative. The discussion highlights that web-based applications might be a viable solution for social media apps to avoid restricting user bases. Ultimately, there is no perfect solution for cross-platform development, as both Apple and Google limit effective cross-platform capabilities.