Here is what I mean by cyclic permutation
Start with the original version of the expression: $$B.0 = u_x^2 n_x^2 (n_y^2+n_z^2) + u_y^2 n_y^2 (n_x^2 + n_z^2) + u_z^2 n_z^2 (n_x^2 + n_y^2)$$Permute the indices according the scheme ##x \rightarrow y \rightarrow z \rightarrow x## to get the first version:$$B.1 = u_y^2 n_y^2 (n_z^2+n_x^2) + u_z^2 n_z^2 (n_y^2 + n_x^2) + u_x^2 n_x^2 (n_y^2 + n_z^2)$$ Permute the first version to get the second version:$$B.2 = u_z^2 n_z^2 (n_x^2+n_y^2) + u_x^2 n_x^2 (n_z^2 + n_y^2) + u_y^2 n_y^2 (n_z^2 + n_x^2)$$ Permute the second version to get:$$B.3 = u_x^2 n_x^2 (n_y^2+n_z^2) + u_y^2 n_y^2 (n_x^2 + n_z^2) + u_z^2 n_z^2 (n_x^2 + n_y^2)$$Note that (a) the last permutation results in the exact form of original expression, i.e. applying the cyclic permutation three times is the identity operation; (b) because addition and multiplication are commutative, the intermediate versions ##B.1## and ##B.2## are equal to the original expression. If I subtract either one from ##B.0##, I get zero.
Your expression is $$E.0=\frac{4}{9}(n_x^4 n_y^4 + n_x^4 n_z^4 + n_y^4 + n_z^4 - n_x^4 n_y^2 n_z^2 - n_x^2 n_y^4 n_z^2 - n_x^2 n_y^2 n_z^4)$$ Permute once to get $$E.1=\frac{4}{9}(n_y^4 n_z^4 + n_y^4 n_x^4 + n_z^4 + n_x^4 - n_y^4 n_z^2 n_x^2 - n_y^2 n_z^4 n_x^2 - n_y^2 n_z^2 n_x^4)$$If I subtract the second expression from the first, I get $$E.0-E.1=\frac{4}{9}(n_x^4 n_y^4 + n_x^4 n_z^4 + n_y^4 + n_z^4-n_y^4 n_z^4 - n_y^4 n_x^4 - n_x^4)\neq 0$$Now ##A##, ##B## and ##C## are invariant (do not change) under a cyclic permutation, therefore ##B^2-4AC## must also be invariant. However, as we have seen, your simplified version of that expression is not. You can perhaps find where you went wrong by verifying that your expressions from one step to the next remain invariant as you simplify.
Also note that ##A## goes as ##n^2## and ##C## goes as ##n^6##. Their product goes as ##n^8##. Now ##B## goes as ##n^4## which means that ##B^2## goes as ##n^8##. Why is this useful? Because if you put together ##B^2-4AC## the sum of the exponents in products of ##n_i## must always be 8. Your simplified expression has mostly eights, but I see two fours. This is a complementary way to pinpointing where you took a wrong turn in your simplification.
Short of actually doing it myself to see what is involved, this is all the help that I can offer at the moment. It looks like a tedious job, but there might a shortcut, I don't know.