To determine if 4^2007 + 2007^4 is a prime number, one approach is to utilize modular arithmetic, which can help identify divisibility. A participant suggests writing a program to compute the result, indicating that the expression is not prime without elaborating further. The discussion emphasizes the importance of mathematical techniques rather than mere speculation. The hint provided suggests that if a prime number p divides the expression, it should be congruent to 0 mod p. Overall, the consensus is that the expression is not prime, and modular arithmetic is a valuable tool for verification.