Solving Digitoxin Rate of Elimination with Geometric Progression

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SUMMARY

The discussion focuses on calculating the total amount of digitoxin in a patient after several months of daily maintenance doses of 0.05mg. The elimination rate of digitoxin is 10% per day, leading to a geometric progression where the common ratio (r) is 0.90. The sum to infinity formula for a geometric series is applied, resulting in a total estimated digitoxin level of 0.50mg. The conversation highlights the importance of assumptions regarding the timing of drug administration and measurement in determining the accuracy of this estimate.

PREREQUISITES
  • Understanding of geometric progression and its formulas
  • Knowledge of pharmacokinetics, specifically drug elimination rates
  • Familiarity with the concept of maintenance dosing in pharmacology
  • Basic algebra for manipulating equations
NEXT STEPS
  • Study the geometric series and its applications in pharmacokinetics
  • Learn about the pharmacokinetics of digitoxin and other cardiac glycosides
  • Explore the impact of dosing schedules on drug levels in the body
  • Investigate methods for measuring drug concentrations in clinical settings
USEFUL FOR

Pharmacologists, medical students, healthcare professionals involved in cardiac care, and anyone interested in the mathematical modeling of drug elimination processes.

lionely
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Homework Statement



Patients with certain heart problems are often treated with digitoxin, a derivative of the digitalis plant. The rate at which a person's body eliminates digitoxin is proportional to the amount present. In 1 day, about 10% of any given amount of the drug will be eliminated. Suppose that a "maintenance dose" of 0.05mg is given daily to a patient. Estimate the total amount of digitoxin that should be present in the patient after several months.


Homework Equations





The Attempt at a Solution



My teacher says there is no answer and that there is a problem with the question. But I don't agree!
Several months compared to 1 day is a lot of time, so I believe the answer is the sum to infinity ,
where

the common ratio r, = 0.90 and a =.05

Also when I write out the terms I noticed that each term is equivalent to the GP sum formula.
Meaning T2 = Sum of first two terms of the sequence if it was a GP.

So I believe T∞ = S∞

S∞ = a/(1-r) = .05/(1-.90 ) = .50mg
 
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lionely said:

Homework Statement



Patients with certain heart problems are often treated with digitoxin, a derivative of the digitalis plant. The rate at which a person's body eliminates digitoxin is proportional to the amount present. In 1 day, about 10% of any given amount of the drug will be eliminated. Suppose that a "maintenance dose" of 0.05mg is given daily to a patient. Estimate the total amount of digitoxin that should be present in the patient after several months.

Homework Equations


The Attempt at a Solution



My teacher says there is no answer and that there is a problem with the question. But I don't agree!
Several months compared to 1 day is a lot of time, so I believe the answer is the sum to infinity ,
where

the common ratio r, = 0.90 and a =.05

Also when I write out the terms I noticed that each term is equivalent to the GP sum formula.
Meaning T2 = Sum of first two terms of the sequence if it was a GP.

So I believe T∞ = S∞

S∞ = a/(1-r) = .05/(1-.90 ) = .50mg

That's a pretty good estimate, but a more exact answer depends on when in the day the patient takes the maintenance dose and when in the day you measure it. What was your assumption? That ambiguity may be what your teacher is talking about.
 
Last edited:
The assumption I made was that it the series is geometric. I guess and that when they ask me about months I consider that a LONG time compared to a day. So hence the SUm to infinity.
 

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