To find the area under a flow versus time graph using MATLAB, numerical integration methods can be employed. The integral can be approximated using techniques such as the midpoint method, which calculates the area between two points by averaging their function values and multiplying by the interval width. For periodic functions, the area under one period can be computed by applying this method across the relevant data points. MATLAB offers built-in functions like 'trapz' for trapezoidal integration and 'quad' for more advanced numerical integration, which can simplify the process. Familiarity with numerical integration schemes is beneficial, and resources like Wikipedia can provide further guidance on various methods available.