Can DNA Be Supercoiled While Wrapped Around Histones?

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SUMMARY

DNA can indeed be supercoiled while wrapped around histones, specifically within its condensed nucleosome structure. In vivo, DNA associated with histones is predominantly negatively supercoiled, which plays a crucial role in DNA compaction and regulation. Electron microscopy images of supercoiled DNA may depict DNA in various states, including those that are histone-bound. Understanding this relationship is essential for comprehending DNA functionality and structure in eukaryotic cells.

PREREQUISITES
  • Basic knowledge of molecular biology concepts, particularly DNA structure.
  • Understanding of histone proteins and their role in chromatin formation.
  • Familiarity with supercoiling and its implications for DNA topology.
  • Knowledge of nucleosome structure and function in eukaryotic cells.
NEXT STEPS
  • Research the mechanisms of DNA supercoiling in eukaryotic cells.
  • Explore the role of histones in regulating gene expression.
  • Learn about techniques for visualizing DNA structures, such as electron microscopy.
  • Investigate the implications of DNA supercoiling on replication and transcription processes.
USEFUL FOR

Biologists, molecular geneticists, and researchers interested in DNA structure, chromatin dynamics, and gene regulation will benefit from this discussion.

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Can DNA be supercoiled while it is wrapped around Histones?

We are often shown in Biology classes electron Photographs of Supercoiled DNA. Would this DNA in the picture be completely free of Histones? Or could the DNA visualised in the picture be supercoiled DNA already in its condensed Nucleosome structure?
 
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I was under the impression that in vivo DNA that was wrapped around histones is predominately negatively supercoiled. Could be wrong.
 

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