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Thapsigargin antiviral research note
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[QUOTE="Ygggdrasil, post: 6452650, member: 124113"] The full text of the article is available here (it should be open access and freely available): [URL]https://www.mdpi.com/1999-4915/13/2/234[/URL] A few notes: [LIST] [*]The evidence in the paper is based on studies of viral replication in cultured cells, which can be a poor model for what occurs in real infections in the human body. Several drugs that seem to work in experiments with cultured cells perform poorly in the clinic (e.g. hydroxychloroquine). [*]Unlike most antiviral drugs (which target proteins encoded by the virus), thapsigargin targets a protein inside of the host cell (an ER calcium pump). While this could account for its ability to prevent replication of a broad spectrum of unrelated viruses, it's also likely that inhibition of that protein is causing a lot of other problems with the cells. Side effects of the drug would be a major concern if it were being delivered systemically, especially if used long term in a prophylactic manner. [/LIST] [/QUOTE]
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