The great basic question of science on origin of life

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The discussion centers on the debate regarding the origin of life, specifically whether life originated from membrane compartments or non-membrane phase compartments (biophase). Matveev's paper argues that the traditional membrane approach lacks experimental support, particularly regarding the sodium-potassium pump's spontaneous emergence under primitive conditions. He emphasizes that non-membrane phase compartments may play a critical role in cellular functions and could provide a more viable explanation for life's origins. Critics highlight the need for a more detailed understanding of pre-cellular processes and express skepticism about the membrane paradigm's validity. The conversation underscores the complexity of defining life and the mechanisms that may have led to its emergence on Earth.
  • #31
Vladimir Matveev said:
The protein matrix of a protocell similar to Fox's microspheres can adsorb amino acids from the environment non-randomly again.
Hi Vladimir:

The Wikipedia summary of Sydney Fox's experiment says that proteins were never produced.
https://en.wikipedia.org/wiki/Sidney_W._Fox
One of the first experiments by Dr. Fox and Kaoru Harada that had to do with the formation of proteinoids was called Thermal Copolymerization of Amino Acids to a Product Resembling Protein. It was performed in February 1958.
The experiment did not prove that proteins were formed on primordial Earth using primarily heat, but Fox and Kaoru Harada believed it suggested that if proteinoids could be synthesized using just heat and the amino acids formed from the Miller–Urey experiment, then more research could lead to an answer to how anabolic reactions, enzymatic proteins, and nucleic acids were first formed and in turn, how the earliest forms of life originated.​
AFAIK, proteinoids have never been demonstrated to have any useful enzymatic properties.
Also AFAIK no scenario has ever been proposed for how hypothetical proteinoids with enzymatic properties could improve by mutation. In contrast, RNA sequences do mutate when reproducing, and RNA ribozymes have been demonstrated to have enzymatic properties.
Regards,
Buzz
 
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  • #32
Thread closed for Moderation...

Edit -- after a Mentor discussion, this thread will remain closed. For those interested in this work, please continue the conversation via private messages. Thank you.
 
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