The great basic question of science on origin of life

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SUMMARY

The forum discussion centers on the debate regarding the origin of life, specifically the role of membrane compartments versus non-membrane phase compartments (biophase). Matveev V.V.'s 2016 paper highlights the inadequacies of existing models, such as the sodium-potassium pump and Fox's microspheres, in explaining life's origins. The conversation critiques the membrane paradigm, advocating for the non-membrane phase approach as a more viable explanation for cellular function and signaling. Participants reference significant works, including de Duve's "Vital Dust," to contrast differing theories on pre-biological steps leading to life.

PREREQUISITES
  • Understanding of biophysics, particularly the principles of membrane physiology.
  • Familiarity with the sodium-potassium pump (Na+/K+-ATPase) and its significance in cellular biology.
  • Knowledge of protocell models, including Sidney Fox's microspheres.
  • Awareness of astrobiology concepts, particularly regarding the conditions of early Earth.
NEXT STEPS
  • Research the implications of non-membrane phase compartments in cellular biology.
  • Explore the role of alkaline hydrothermal vents in the origin of life, referencing Keller et al.'s findings.
  • Investigate the critiques of the membrane paradigm in contemporary biophysics literature.
  • Examine the historical context and scientific contributions of Christian de Duve's work on the origin of life.
USEFUL FOR

Researchers in astrobiology, biophysicists, and anyone interested in the fundamental questions surrounding the origin of life and cellular evolution.

  • #31
Vladimir Matveev said:
The protein matrix of a protocell similar to Fox's microspheres can adsorb amino acids from the environment non-randomly again.
Hi Vladimir:

The Wikipedia summary of Sydney Fox's experiment says that proteins were never produced.
https://en.wikipedia.org/wiki/Sidney_W._Fox
One of the first experiments by Dr. Fox and Kaoru Harada that had to do with the formation of proteinoids was called Thermal Copolymerization of Amino Acids to a Product Resembling Protein. It was performed in February 1958.
The experiment did not prove that proteins were formed on primordial Earth using primarily heat, but Fox and Kaoru Harada believed it suggested that if proteinoids could be synthesized using just heat and the amino acids formed from the Miller–Urey experiment, then more research could lead to an answer to how anabolic reactions, enzymatic proteins, and nucleic acids were first formed and in turn, how the earliest forms of life originated.​
AFAIK, proteinoids have never been demonstrated to have any useful enzymatic properties.
Also AFAIK no scenario has ever been proposed for how hypothetical proteinoids with enzymatic properties could improve by mutation. In contrast, RNA sequences do mutate when reproducing, and RNA ribozymes have been demonstrated to have enzymatic properties.
Regards,
Buzz
 
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  • #32
Thread closed for Moderation...

Edit -- after a Mentor discussion, this thread will remain closed. For those interested in this work, please continue the conversation via private messages. Thank you.
 
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