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Inverted Protein: Does Sequence Matter?
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[QUOTE="Eagle9, post: 6046187, member: 216581"] Good day! :oldsmile: Imagine the mRNA with some nucleotide sequence that (after translation) will give us such polypeptide chain: [URL='https://en.wikipedia.org/wiki/Alanine']L-Alanine[/URL] (first, in the beginning of translation) - [URL='https://en.wikipedia.org/wiki/Arginine']L-Arginine[/URL] - [URL='https://en.wikipedia.org/wiki/Asparagine']L-Asparagine[/URL] - [URL='https://en.wikipedia.org/wiki/Aspartic_acid']L-Aspartic acid[/URL] - [URL='https://en.wikipedia.org/wiki/Cysteine']L-Cysteine[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamic_acid']L-Glutamic acid[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamine']L-Glutamine[/URL] - [URL='https://en.wikipedia.org/wiki/Glycine']Glycine[/URL] (last, in the end of translation) Such (or imagine longer one, its length is not crucial in my question) chain will fold after translation and we will get some certain protein. Now imagine the polypeptide chain with inverted sequence, that is first we get (from ribosome) [URL='https://en.wikipedia.org/wiki/Glycine']Glycine[/URL], then [URL='https://en.wikipedia.org/wiki/Glutamine']L-Glutamine[/URL] and so on: [URL='https://en.wikipedia.org/wiki/Glycine']Glycine[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamine']L-Glutamine[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamic_acid']L-Glutamic acid[/URL] - [URL='https://en.wikipedia.org/wiki/Cysteine']L-Cysteine[/URL] - [URL='https://en.wikipedia.org/wiki/Aspartic_acid']L-Aspartic acid[/URL] - [URL='https://en.wikipedia.org/wiki/Asparagine']L-Asparagine[/URL] - [URL='https://en.wikipedia.org/wiki/Arginine']L-Arginine[/URL] - [URL='https://en.wikipedia.org/wiki/Alanine']L-Alanine[/URL] This chain will also fold, but what we will receive? The same protein? If the folding process depends only on polypeptide contents (number of amino acids, their chemical properties and sequence) then this “invertness” would not matter and we should get two identical proteins, right? But if the folding process (and final product) begins as soon as polypeptide chain (more precisely its part) exits ribosome then we will have different amino acid sequencing to fold, in first case we have [URL='https://en.wikipedia.org/wiki/Alanine']L-Alanine[/URL] - [URL='https://en.wikipedia.org/wiki/Arginine']L-Arginine[/URL] - [URL='https://en.wikipedia.org/wiki/Asparagine']L-Asparagine[/URL]…………… and in second case: [URL='https://en.wikipedia.org/wiki/Glycine']Glycine[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamine']L-Glutamine[/URL] - [URL='https://en.wikipedia.org/wiki/Glutamic_acid']L-Glutamic acid[/URL]……………. So, what do you think? :oldeyes: [/QUOTE]
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Inverted Protein: Does Sequence Matter?
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