To solve the integral involving y.du/(y^2 + (x - u)^2), a substitution is needed to simplify the integrand. The integrand resembles 1/(1+x^2), which has an antiderivative of arctan(x). By taking y out of the integral and substituting b = x - u, with db = -du, the expression can be transformed. This leads to the result of -tan^(-1)((x-u)/y) as the antiderivative. The discussion emphasizes the importance of appropriate substitutions to match known integral forms.