Yes, doing this eliminates the need for the chain rule in the numerator, so by cancelling the e^(2x), we are simplifying the numerator, and completely eliminating the denominator (i.e., turning the denominator to 1), and thereby making the entire expressing non-indeterminate form.
The best thing to do is to try to turn the expression into a rational one (a ratio of two expressions), and then trying to simplify the numerator if necessary. Sometimes you will be able to take the derivative of the top and bottom easily, but when you cannot, then try to manipulate the expression a little bit in your favor. Look for similar terms, anything that can lead to an expression that is easier to work with.
Unfortunately, depending on the problem, this might be easier said than done. But perseverance is key!