Using DNA as Memory in Biocomputers: Current Research and Potential Applications

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SUMMARY

The discussion centers on the exploration of using DNA and protein macromolecules as memory storage in biocomputers. Researchers are investigating the feasibility of encoding binary data using DNA base pairs, specifically pairing A&T as 0 and G&C as 1. Current challenges include the high costs associated with reading human genomes, which hinder the practical application of DNA computing. Until a self-contained, reusable biochemical system is developed for efficient DNA data processing, commercial viability remains limited.

PREREQUISITES
  • Understanding of DNA structure and function
  • Familiarity with binary encoding concepts
  • Knowledge of biocomputing principles
  • Awareness of current DNA sequencing technologies
NEXT STEPS
  • Research recent advancements in DNA computing technologies
  • Explore the implications of Craig Venter's gene programming techniques
  • Investigate the development of self-contained biochemical systems for DNA data processing
  • Study the potential of plasmids in biocomputing applications
USEFUL FOR

Researchers, biocomputing enthusiasts, and professionals in biotechnology and computer science interested in the intersection of biology and computing technologies.

moogull
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Is there any research being done on using DNA or big long protein macromolecules as machinery for memory in computing? The ability to pack in so much information in a long string of protein because of how proteins can fold is vast. Has anyone proposed making DNA that into a binary entity, like taking taking an A&T pair to be 0 and G&C pair to be 1? How plausible is this?
If Craig Venter can program a gene code then why not be able to use the gene code to program?
 
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DNA computing is indeed being investigated, these are a selection of papers from the last 5 years alone
http://scholar.google.co.uk/scholar?hl=en&q=DNA+computing&as_sdt=0,5&as_ylo=2007&as_vis=1

The problem is that it is not quite so simple. Reading a human genome costs a few hundred to a few thousand dollars, if you had to pay that much expense every time you wanted to read something from your hard drive you'd be broke pretty quickly! Until a self contained, reusable unit can be developed that contains all the necessary biochemical machinery to read, write and compute on DNA in a reasonable time we won't be seeing commercial DNA computing.
 
Yeah, but I want it now! All kidding aside, the only biology exposure I have is a couple intro bio courses in college and some reading aside, but perhaps it could be scaled down to little "8-bit chromosomes" or 16-bit or w.e is best for the scale. Or, I feel like in theory plasmids of these sizes could be passed back and forth and manipulated between specially programmed inert bacteria, does this idea make sense?
 

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