A bit of a digression, but the Apollo 1 fire has already been mentioned, and it is relevant to the tradeoffs between pressure and composition of atmosphere...
Apollo 1 was designed to operate in space with about 5 psi internal pressure, about what you'd find at the top of the highest mountain peaks. This lowered the required structural strength and hence the weight of the spacecraft , but required an oxygen atmosphere just as mountaineers require oxygen at altitude. (The oxygen atmosphere also simplified preparations for space walks, as the space suits operated on pure oxygen).
However, on the ground the capsule is subject to 14.7 psi external air pressure and cannot be operated with negative internal pressure, so the Apollo 1 test was done at an internal pressure of a bit over 16 psi. 16 psi oxygen is an extraordinarily high fire risk - any random spark can turn anything that will oxidize in air when heated into pyrotechnics, and that's what happened to Apollo 1.
There were several other oxygen atmosphere accidents at about that time and together they led to a consensus that the engineering advantages of pure oxygen atmospheres justified the fire risk only when low pressure and weight was absolutely paramount. And even then much effort goes into eliminating flammable materials around oxygen under pressure.