SUMMARY
The discussion focuses on identifying superior coupling reagents for the reaction between amines and carboxylic acids. The user currently employs TBTU with fenchyl amine hydrochloride but reports a lack of reactivity. Recommended alternatives include CDI, HOBT, DCC, and EDCI, which are frequently cited in the literature. A resource listing various coupling reagents along with their CAS numbers is provided for further reference.
PREREQUISITES
- Understanding of amine and carboxylic acid chemistry
- Familiarity with coupling reagents such as TBTU, CDI, HOBT, DCC, and EDCI
- Knowledge of chemical reaction mechanisms
- Access to chemical catalogs for cross-referencing CAS numbers
NEXT STEPS
- Research the mechanisms of action for CDI and HOBT as coupling reagents
- Explore the advantages and limitations of DCC and EDCI in peptide synthesis
- Investigate alternative coupling reagents listed on the provided GLS China resource
- Review literature on optimizing amine and carboxylic acid reactions
USEFUL FOR
Chemists, researchers in organic synthesis, and anyone involved in peptide synthesis or coupling reactions will benefit from this discussion.