Parameters in physics are fixed values that define specific characteristics of a model, such as gravitational acceleration (g=9.8 m/s²) and the speed of light (c=300,000 km/s). In contrast, variables represent values that can change within the model, typically the outcomes being calculated. Parameters remain constant during analysis, allowing only the variable to change, which helps clarify the relationship being studied. For instance, in the quadratic function f(x) = ax² + bx + c, a, b, and c are treated as parameters while x is the variable. Understanding this distinction is crucial for accurately interpreting mathematical and physical models.