I propose a slightly different way to look at this. The normal SC charts have M>0, and (1) r > 2M, and (2) r ∈ (0,2M). If you do R= -r as a pure coordinate transform, nothing changes about the physics because the relevant charts now have M>0 with (1) R < -2M and (2) R ∈ (-2M,0). Further, the event (t,R,θ,φ)=(t,-n,θ,φ) is taken to be the same as (t,r,θ,φ)= (t,n,θ,φ).
However, taking the SC metric as given, with M > 0, and asking about a new 'region' charted with r < 0 representing a different event than r >0, produces a physically different region (I put region in quotes because it is not possible to extend geodesics across r=0; this is not an 'extension' of the normal SC geometry). This region is physically the same as with M < 0, and r > 0. Given the semantics of r for spherical symmetry, it is simply more sensible to describe this geometry in terms of M<0, r >0. This geometry is not the same the white hole region of the KS analytic extension of an M>0 SC chart. It is simply a physically different geometry.