When to use negative signs with electric field vectors?

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LakeMountD
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Using the equation E= (kq)/(R)^2 in the r direction. I am confused on when to make the vector negative in my equations. For instance if you had a charge on x=0 and x=5 (on the x axis) and then you want to find the field at point (1,1) or something like this.
 
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Consider an electric charge "q" in the origin of the coordinate system.The electric field at at a point of coordinate vector [tex]\vec{r}[/tex] is

[tex]\vec{E}=\frac{q}{4\pi\epsilon_{0}\epsilon_{r}|\vec{r}|^{2}}\frac{\vec{r}}{|\vec{r}|}[/tex]

That's all.

Daniel.
 
The direction of the vector is the same as the direction from the source point to the field point - multiplied by the sign of the charge.