Where and How are tRNA's Synthesized?

[ARAVIND113122]

mRNA is synthesized during transcription,but where and how are the tRNA's synthesized?

 

[Ygggdrasil]

tRNAs are also made by transcription, by a different RNA polymerase (RNA polymerase III) than is used for mRNA synthesis (RNA polymerase II). Because the factors involved in mRNA capping and polyadenylation are physically associated with RNA polymerase II and not RNA polymerase III, tRNAs do not undergo capping and polyadenylation like mRNAs. tRNAs, however do undergo extensive post-transcriptional processing to get them into their final form.

 

[That Neuron]

tRNAs are also made by transcription, by a different RNA polymerase (RNA polymerase III) than is used for mRNA synthesis (RNA polymerase II). Because the factors involved in mRNA capping and polyadenylation are physically associated with RNA polymerase II and not RNA polymerase III, tRNAs do not undergo capping and polyadenylation like mRNAs. tRNAs, however do undergo extensive post-transcriptional processing to get them into their final form.

So you need tRNA molecules to create more tRNA molecules? Because I would think initial tRNA is necessary to create RNA polymerase, Thats interesting, wonder how the first tRNA evolved. And you would need a DNA sequence that aligned with the produced type of tRNA in order to create proteins, maybe DNA evolved around tRNA... Hmmmm Hahah, Off topic, I know.

 

[Ryan_m_b]

So you need tRNA molecules to create more tRNA molecules? Because I would think initial tRNA is necessary to create RNA polymerase, Thats interesting, wonder how the first tRNA evolved. And you would need a DNA sequence that aligned with the produced type of tRNA in order to create proteins, maybe DNA evolved around tRNA... Hmmmm Hahah, Off topic, I know.

What's fascinating about RNA is that it can act both as genetic material (like DNA) and as enzymatic molecules (like proteins) e.g http://en.wikipedia.org/wiki/Ribozyme" posits that early life used RNA in both capacities until the evolution of proteins took over most of the jobs.

 

[That Neuron]

What's fascinating about RNA is that it can act both as genetic material (like DNA) and as enzymatic molecules (like proteins) e.g http://en.wikipedia.org/wiki/Ribozyme" posits that early life used RNA in both capacities until the evolution of proteins took over most of the jobs.

Ahh yeah I've head of Ribozymes before, I'll have to look more into that. http://www.newscientist.com/article/dn18623-did-midwife-molecule-assemble-first-life-on-earth.html might find this interesting aswell