Why Do Helical Viruses Remain Attached?

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SUMMARY

Helical viruses maintain attachment between their genetic material and protein shell due to electrostatic interactions, specifically between negatively charged nucleic acids and positively charged proteins. At a neutral pH of 7, nucleic acids lose hydrogen ions, resulting in a negative charge, while proteins gain hydrogen ions, leading to a positive charge. This charge stability prevents disassociation unless external factors, such as the introduction of a negatively charged object, disrupt this balance. Understanding these interactions is crucial for developing methods to inhibit viral activity.

PREREQUISITES
  • Basic understanding of molecular biology concepts, particularly nucleic acids and proteins
  • Knowledge of acid/base reactions and their effects on molecular charge
  • Familiarity with pH levels and their biological implications
  • Concepts of electrostatics in biological systems
NEXT STEPS
  • Research methods for manipulating pH levels in biological systems
  • Explore techniques for chelation and its applications in viral inhibition
  • Study the structural biology of helical viruses and their capsid interactions
  • Investigate the role of electrostatic interactions in protein-nucleic acid binding
USEFUL FOR

Biologists, virologists, and researchers focused on viral mechanisms and potential therapeutic interventions will benefit from this discussion.

Brainguy
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according to http://en.wikipedia.org/wiki/Virus_(biology)
helical viruses keep their genetic material in place because of "interactions between the negatively charged nucleic acid and positive charges on the protein". Why do these two structures continue to be attached to each other? I would expect them to disconnect as soon as soon as the extra electrons in the RNA neutralize the ions in the protein shell. And why are they both charged in the first place?
thanks,
-brainguy
 
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Electrons in the are not free to move to other molecules as they are in non-bonding molecular orbitals.

The RNA and proteins acquires charge through acid/base reactions. At pH 7, it is thermodynamically favorable for the neutrally-charged hydrogen phosphate groups in nucleic acids to transfer a hydrogen to water, forming a negatively-charged phosphate and a positively-charged hydronium ion (H3O+). Similarly, at neutral pH, proteins contain basic groups that will accept a hydrogen from water in order to become positively-charged.
 
I know this is old, but I asked because I was wondering if the nucleic acids could be made to fall out of the capsid if either the capsid or the nucleic acid lost its charge. Here's another question, are the molecules in the capsid willing to accept more electrons? if so, a negatively charged object could be placed near the virus,causing the protein to neutralize and the nucleic acids to fall out of the capsid, rendering the virus inert?
-brainguy
 
you want a way to bind/inhibit the viral molecules like chelation?
 

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