Why Do Helical Viruses Remain Attached?

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Discussion Overview

The discussion centers on the interactions between helical viruses' genetic material and their protein shells, specifically exploring the reasons for their attachment and the implications of charge dynamics. The scope includes theoretical considerations and speculative inquiries regarding the stability of these structures.

Discussion Character

  • Exploratory, Conceptual clarification, Debate/contested

Main Points Raised

  • Some participants propose that helical viruses maintain attachment between nucleic acids and proteins due to electrostatic interactions, questioning the stability of this bond under changing charge conditions.
  • One participant explains that the charges on RNA and proteins arise from acid/base reactions at neutral pH, suggesting that this charge is essential for maintaining their interaction.
  • A later reply raises the possibility that if either the capsid or nucleic acid lost its charge, it could lead to disassociation, speculating on the effects of external negatively charged objects on the virus's stability.
  • Another participant suggests the idea of using chelation to inhibit viral molecules, indicating a potential method for disrupting these interactions.

Areas of Agreement / Disagreement

Participants express differing views on the stability of the interactions between nucleic acids and proteins, with some exploring the implications of charge changes while others propose methods for inhibition. The discussion remains unresolved regarding the mechanisms and potential interventions.

Contextual Notes

Limitations include assumptions about the behavior of charges in biological systems and the specific conditions under which these interactions occur, which are not fully explored.

Who May Find This Useful

Readers interested in virology, molecular biology, and the interactions of charged biomolecules may find this discussion relevant.

Brainguy
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according to http://en.wikipedia.org/wiki/Virus_(biology)
helical viruses keep their genetic material in place because of "interactions between the negatively charged nucleic acid and positive charges on the protein". Why do these two structures continue to be attached to each other? I would expect them to disconnect as soon as soon as the extra electrons in the RNA neutralize the ions in the protein shell. And why are they both charged in the first place?
thanks,
-brainguy
 
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Electrons in the are not free to move to other molecules as they are in non-bonding molecular orbitals.

The RNA and proteins acquires charge through acid/base reactions. At pH 7, it is thermodynamically favorable for the neutrally-charged hydrogen phosphate groups in nucleic acids to transfer a hydrogen to water, forming a negatively-charged phosphate and a positively-charged hydronium ion (H3O+). Similarly, at neutral pH, proteins contain basic groups that will accept a hydrogen from water in order to become positively-charged.
 
I know this is old, but I asked because I was wondering if the nucleic acids could be made to fall out of the capsid if either the capsid or the nucleic acid lost its charge. Here's another question, are the molecules in the capsid willing to accept more electrons? if so, a negatively charged object could be placed near the virus,causing the protein to neutralize and the nucleic acids to fall out of the capsid, rendering the virus inert?
-brainguy
 
you want a way to bind/inhibit the viral molecules like chelation?
 

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