Why Do Helical Viruses Remain Attached?

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Helical viruses maintain their genetic material through interactions between negatively charged nucleic acids and positively charged proteins. These charges arise from acid/base reactions at neutral pH, where nucleic acids lose hydrogen ions, becoming negatively charged, while proteins gain hydrogen ions, becoming positively charged. The discussion raises questions about the stability of these interactions and whether altering the charges could lead to the nucleic acids detaching from the capsid. It also explores the potential for using external negatively charged objects to neutralize the protein's charge, which could render the virus inactive by causing the nucleic acids to fall out of the capsid. The concept of using chelation to inhibit viral molecules is also mentioned as a possible strategy.
Brainguy
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according to http://en.wikipedia.org/wiki/Virus_(biology)
helical viruses keep their genetic material in place because of "interactions between the negatively charged nucleic acid and positive charges on the protein". Why do these two structures continue to be attached to each other? I would expect them to disconnect as soon as soon as the extra electrons in the RNA neutralize the ions in the protein shell. And why are they both charged in the first place?
thanks,
-brainguy
 
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Electrons in the are not free to move to other molecules as they are in non-bonding molecular orbitals.

The RNA and proteins acquires charge through acid/base reactions. At pH 7, it is thermodynamically favorable for the neutrally-charged hydrogen phosphate groups in nucleic acids to transfer a hydrogen to water, forming a negatively-charged phosphate and a positively-charged hydronium ion (H3O+). Similarly, at neutral pH, proteins contain basic groups that will accept a hydrogen from water in order to become positively-charged.
 
I know this is old, but I asked because I was wondering if the nucleic acids could be made to fall out of the capsid if either the capsid or the nucleic acid lost its charge. Here's another question, are the molecules in the capsid willing to accept more electrons? if so, a negatively charged object could be placed near the virus,causing the protein to neutralize and the nucleic acids to fall out of the capsid, rendering the virus inert?
-brainguy
 
you want a way to bind/inhibit the viral molecules like chelation?
 
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