Zone 1 of the liver, known as the periportal zone, is more susceptible to ischemic injury due to its reliance on the hepatic portal vein, which supplies approximately half of the liver's oxygenation under normal conditions. In cirrhosis, this oxygen supply is diminished, increasing the risk of injury. Eclampsia can exacerbate this condition by causing vascular damage, further compromising oxygen delivery. Zone 3, in contrast, is the least oxygenated and most prone to ischemic injury.
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sameeralord said:Hi,
Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why does eclampsia cause zone 1 necrosis. Thanks :)
SW VandeCarr said:Zone 1 is the periportal zone. Although a vein, the portal vein supplies about half the liver's oxygenation in the normal situation, but this is reduced in cirrhosis. The hepatic artery normally supplies the other half. Zone 1 is more prone to toxic and viral injury (hepatitis). Zone 3 is normally the least oxygenated of the hepatic zones and the most prone to ischemic injury.
mazinse said:double check here, the portal vein shouldn't have any oxygen you mean nutrients right from the GI.
to the original question, ecclampsia is a vascular damage, so yeah the logic stands