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X linked gene but more common in females?
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[QUOTE="epenguin, post: 5715492, member: 106258"] Another possibility is 'dosage effect'. That is a characteristic that for full expression needs to doses of the allele. One dose gives a weak effect, but more visible or more expressed when the overall coat colour is pale? We probably haven't exhausted the possibilities. Er - I printed out the question, these imaginary cats are done very well, then came back and answered. I felt a bit uneasy because I have heard of gene dosage, but also of X inactivation. Then I saw Jim McNamara's post. However doesn't the inactivation take place at certain developmental stages? So that you can have mosaicism – a given gene being expressed in half the cells. Unfortunately I do not well remember and am not very up-to-date. Could you explain by supposing the spotted phenotype in females to be the result of non-expression are of a certain gene in half the cells? That it is just the mosaicism that causes the spots? That it would be a rare in males because either expression of the allele in question in all the cells or non-expression in all the cells gives rise to the uniform colour? [/QUOTE]
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X linked gene but more common in females?
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