All those who replied here, have given some excellent suggestions! It is also fun to observe, from how many different directions we approach this question.
My earlier response was made from an empirical perspective.. In other words, suppose you didn't know that force is directly proportional to acceleration and you conducted this experiment. You could plot the data, observe that
it seems to be linear and draw by
eyeball your best line through the points and read the y-intercept directly off the graph. You could take all the (change-y / change-x) differences and average them for the slope. Since no criteria for precision was given, this may be accurate enough. Or you can apply statistics and find a line using linear regression method.
If you repeated the experiment a few more times, you may converge to a better representation of y-values (acceleration) or if there is imprecision in the experiment, you may find more variation.
But if you knew ahead of time (from theory), that there was a perfectly linear relationship and that 0 force would yield 0 acceleration (giving you the y-intercept); then I would make some assumptions as have been suggested, maybe even exclude
outlier data points, before calculating the slope. But then I would be biasing the data in a direction I thought it should be heading (If you're practising science, it's best not to fudge your results to fit what you believe, even Einstein made that mistake).