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Eigen-Wilkins mechanism

by Amok
Tags: eigenwilkins, mechanism
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Amok
#1
Jan28-12, 08:36 AM
P: 255
Hi,

Can anyone help derive the rate law for the Eigen wilkins reaction mechanism? The derivation in the wikipedia entry (http://en.wikipedia.org/wiki/Eigen-Wilkins_Mechanism) is confusing, but the rate law is correct. I can't figure out if they make a "steady-state" approximation or a pre-equilibrium approximation, but I'm pretty sure it's both (weird).
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Ygggdrasil
#2
Jan28-12, 09:20 PM
Other Sci
Sci Advisor
P: 1,384
The equation looks very similar to the Michaelis-Menten (MM) equation used in biochemistry if you substitute [Y] for [S], [M]tot for [E]0, and KE for 1/KM (see equation 11 from the link below). The MM equation is similarly derived by assuming a mechanism whereby two molecules form an initial encounter complex that converts to product in the rate limiting step. The MM equation can be derived solely by using the steady-state approximation, for example, see the following site for a derivation: http://biofitweb.cox-thurmond.net/Fi...derivation.htm
Amok
#3
Jan29-12, 03:26 AM
P: 255
I tried it and it's not exactly the same. Unfortunately I don't have access to the original article that gives the derivation, but in the abstract they say they use a pre-equilbirum. But maybe I missed something, I'll try it again.


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