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EigenWilkins mechanism 
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#1
Jan2812, 08:36 AM

P: 255

Hi,
Can anyone help derive the rate law for the Eigen wilkins reaction mechanism? The derivation in the wikipedia entry (http://en.wikipedia.org/wiki/EigenWilkins_Mechanism) is confusing, but the rate law is correct. I can't figure out if they make a "steadystate" approximation or a preequilibrium approximation, but I'm pretty sure it's both (weird). 


#2
Jan2812, 09:20 PM

Other Sci
Sci Advisor
P: 1,400

The equation looks very similar to the MichaelisMenten (MM) equation used in biochemistry if you substitute [Y] for [S], [M]tot for [E]0, and K_{E} for 1/K_{M} (see equation 11 from the link below). The MM equation is similarly derived by assuming a mechanism whereby two molecules form an initial encounter complex that converts to product in the rate limiting step. The MM equation can be derived solely by using the steadystate approximation, for example, see the following site for a derivation: http://biofitweb.coxthurmond.net/Fi...derivation.htm



#3
Jan2912, 03:26 AM

P: 255

I tried it and it's not exactly the same. Unfortunately I don't have access to the original article that gives the derivation, but in the abstract they say they use a preequilbirum. But maybe I missed something, I'll try it again.



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