- #1
espen180
- 834
- 2
I have been thinking about attempting a synthesis of nitrobenzene compounds, with a long-term prospect of synthesizing aspirin.
I have some questions regarding the synthesis.
During the addition of the nitro group to benzene, I only want molecules with a single nitro group. How do I minimize the yield of multinitrobenzene compounds? During the addition, the reaction container is to be kept below 55 degrees celcius. Is this the temperature multinitrobenzene compounds start forming?
Once I have the nitrobenzene, I plan on doing a series of reactions to make phenol. I then need to add a second hydroxy group.
1. How high yield can I hope for when making phenol from benzene using this method?
2. When adding the nitro group to the phenol, I need it in the orto-position. I'm suspecting about 66% of the compounds will satisfy this, so what is the best way of separating the ortonitrophenol from the paranitrophenol?
Any feedback is appreciated.
I have some questions regarding the synthesis.
During the addition of the nitro group to benzene, I only want molecules with a single nitro group. How do I minimize the yield of multinitrobenzene compounds? During the addition, the reaction container is to be kept below 55 degrees celcius. Is this the temperature multinitrobenzene compounds start forming?
Once I have the nitrobenzene, I plan on doing a series of reactions to make phenol. I then need to add a second hydroxy group.
1. How high yield can I hope for when making phenol from benzene using this method?
2. When adding the nitro group to the phenol, I need it in the orto-position. I'm suspecting about 66% of the compounds will satisfy this, so what is the best way of separating the ortonitrophenol from the paranitrophenol?
Any feedback is appreciated.