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What factors affect the time taken for a drug to reach steadystate? 
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#1
Jul1013, 08:54 PM

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Hi all,
To be more specific, do the following factors increase the time taken for a drug to reach steadystate? Increased frequency of drug administration Increased dosage of drug administration If not, please explain why that is the case. Many thanks, Jay 


#2
Jul1013, 09:31 PM

Mentor
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#3
Jul1013, 10:33 PM

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#4
Jul1113, 12:06 AM

P: 2,501

What factors affect the time taken for a drug to reach steadystate?
There are many things that affect the steady state plasma concentrations for a given drug. Both the size of the individual dose and the number of doses taken per day are important and you can't say a priori which is more important. The plasma concentration at steady state is dose dependent but the time to steady state is dependent on the elimination half life.
The link below is essentially a minicourse in pharmacokinetics. It contains some very simple differential equations so I think a basic knowledge of calculus, if that, is all you need to follow the course. http://www.pharmpress.com/files/docs...plechapter.pdf It also contains some case studies which may or not interest you. They are not essential to understanding such concepts as elimination half life, volume of distribution, one and two compartment models, etc. 


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