- #1
sameeralord
- 662
- 3
Hello everyone,
A 20 year old insulin dependent diabetic female was admitted to casuality in a semiconscious state. Her plasma values are as follows. a) on admission, b)eight hour after therapy with insulin,saline etc.
Na+ a) 127, b)134, normal- 132-144 mmol/l
K+ a) 7.0, b)3.1, normal- 3.2-4.8 mmol/l
Urea a) 10.1, b)6.0, normal- 3.0-8.0 mmol/l
Creatinine a) 0.18, b)0.07, normal- 0.06-0.12 mmol/l
Phosphate a) 1.85, b)0.30, normal- 0.6-1.3 mmol/l
This is what I think why these values have changed. Please add and correct me if I'm wrong.
Na+ = Sodium has decreased initially. Due to osmotic diuresis. Large amount of sodium is lost in urine. I'm also thinking lack of insulin depresses the ativity of sodium potassium atpase pump, so more sodium enters cells not sure about this.
K+ = Sodium potassium pump depression, creating efflux of Potassium. Also due to osmotic diuresis, water is lost so this increases plasma K+ concentration. Also after insulin treatment K+ moves into cells due to increased activity of sodium pottasium pump.
Urea, creatinine, phosphte= Are they increased due to water loss or is diabetic nephropahy involved in this. If Diabetic nephropathy is involved how can they become normal after treatment.
Your help is much appreciated. Thanks
A 20 year old insulin dependent diabetic female was admitted to casuality in a semiconscious state. Her plasma values are as follows. a) on admission, b)eight hour after therapy with insulin,saline etc.
Na+ a) 127, b)134, normal- 132-144 mmol/l
K+ a) 7.0, b)3.1, normal- 3.2-4.8 mmol/l
Urea a) 10.1, b)6.0, normal- 3.0-8.0 mmol/l
Creatinine a) 0.18, b)0.07, normal- 0.06-0.12 mmol/l
Phosphate a) 1.85, b)0.30, normal- 0.6-1.3 mmol/l
This is what I think why these values have changed. Please add and correct me if I'm wrong.
Na+ = Sodium has decreased initially. Due to osmotic diuresis. Large amount of sodium is lost in urine. I'm also thinking lack of insulin depresses the ativity of sodium potassium atpase pump, so more sodium enters cells not sure about this.
K+ = Sodium potassium pump depression, creating efflux of Potassium. Also due to osmotic diuresis, water is lost so this increases plasma K+ concentration. Also after insulin treatment K+ moves into cells due to increased activity of sodium pottasium pump.
Urea, creatinine, phosphte= Are they increased due to water loss or is diabetic nephropahy involved in this. If Diabetic nephropathy is involved how can they become normal after treatment.
Your help is much appreciated. Thanks