How does estradiol level rise pre-LH surge?

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In summary, estradiol is produced by the ovaries in response to signals from the pituitary gland, specifically follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The increase in estradiol levels before the LH surge is due to the development of follicles in the ovaries, which produce more estradiol as they grow. This timing can vary among individuals and can be affected by factors such as age, hormonal imbalances, and underlying health conditions. The body knows when to produce more estradiol before the LH surge through signals from the pituitary gland and this can affect fertility if there are fluctuations in estradiol levels. Monitoring estradiol levels and consulting with a
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seratia
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In the follicular phase, once the estradiol level reaches a certain threshold, it causes a switch from negative feedback to positive feedback on LH & FSH. That is why we have a surge near the end of the follicular phase.

My question is, what makes estradiol rise and reach that threshold to begin with, if it is under negative feedback initially. Shouldn't it not rise, because of negative feedback on LH & FSH?
 
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1. How does the level of estradiol rise before the LH surge?

The level of estradiol rises before the LH surge due to the increase in production of follicle-stimulating hormone (FSH) by the pituitary gland. FSH stimulates the growth and development of the ovarian follicles, which then produce estradiol. As the follicles grow and mature, they release more and more estradiol into the bloodstream, leading to a rise in estradiol levels.

2. What role does estradiol play in the menstrual cycle?

Estradiol is a type of estrogen hormone that plays a crucial role in the menstrual cycle. It is responsible for thickening the uterine lining, preparing it for potential pregnancy. Estradiol also helps regulate the production of other hormones, such as LH and progesterone, which are necessary for ovulation and maintaining a healthy pregnancy.

3. What factors can affect estradiol levels?

There are several factors that can affect estradiol levels, including age, stress, exercise, and certain medications. As women age, their estradiol levels naturally decrease. Stress and intense exercise can also temporarily lower estradiol levels. Certain medications, such as birth control pills and hormone replacement therapy, can also impact estradiol levels.

4. How can I measure my estradiol levels?

Estradiol levels can be measured through a blood test. This test is usually done on the third day of a woman's menstrual cycle, as estradiol levels are typically at their lowest during this time. In some cases, a urine test may also be used to measure estradiol levels.

5. What happens to estradiol levels after the LH surge?

After the LH surge, estradiol levels continue to rise until they reach their peak. This peak triggers the release of an egg from the ovary, known as ovulation. After ovulation, estradiol levels begin to decrease, and the follicle that released the egg turns into the corpus luteum, which produces progesterone to support a potential pregnancy.

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