Is Renin an enzyme or a hormone?

Medical
Thread starter red65
Start date Jan 23, 2023
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hormones

In summary, renin is considered both an enzyme and a hormone in the body. Its main role is to regulate blood pressure and fluid balance by converting angiotensinogen into angiotensin I, which leads to the production of angiotensin II. Renin is primarily produced in the juxtaglomerular cells of the kidney and can also be produced in other tissues. Various factors such as blood pressure, sodium levels, hormones, stress, and medications can affect renin levels. Renin levels can be tested through a blood test, which can help diagnose and monitor conditions related to the renin-angiotensin-aldosterone system.

Jan 23, 2023

red65

Hello everyone, renin is mentioned sometimes as a hormone and others as an enzyme, is it both? can anyone tell me the final answer?

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Jan 23, 2023

BillTre

Science Advisor

Gold Member

Have you tried googling renin?

Jan 23, 2023

Godot_

Wikipedia will tell you the core facts, no use reinventing the wheel...

1. Is Renin an enzyme or a hormone?

Renin is an enzyme, specifically a proteolytic enzyme, that is produced and secreted by the kidneys. It plays a crucial role in the renin-angiotensin-aldosterone system, which regulates blood pressure and fluid balance in the body.

2. What is the function of Renin?

The main function of Renin is to convert angiotensinogen (a protein produced by the liver) into angiotensin I. This then undergoes further conversion in the lungs to form angiotensin II, a potent vasoconstrictor that helps to increase blood pressure and stimulate the release of aldosterone.

3. How is Renin regulated in the body?

Renin production and secretion is regulated by various factors including blood pressure, sodium levels, and sympathetic nervous system activity. When there is a decrease in blood pressure or sodium levels, or an increase in sympathetic activity, it triggers the release of Renin from the kidneys.

4. Can Renin be inhibited?

Yes, there are medications that can inhibit the activity of Renin, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). These drugs are commonly used to treat hypertension and other conditions related to the renin-angiotensin-aldosterone system.

5. Is Renin only found in the kidneys?

While the kidneys are the primary source of Renin production, it can also be found in other tissues such as the brain, heart, and adrenal glands. However, the majority of Renin in the body is produced and secreted by the kidneys.