Molecular Mechanisms Behind Maternal Age and Down Syndrome Risk

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In summary, Down syndrome is caused by an extra copy of chromosome 21 during the formation of reproductive cells or early fetal development. The risk of having a child with Down syndrome increases with maternal age, but there is currently no known way to prevent it. The condition is not caused by environmental factors or influenced by a mother's health during pregnancy.
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Tyto alba
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Why does increase in age of the mother increases the chance of having an offspring with Down Syndrome?

I want to know the molecular basis of this observation. I'll be grateful if somebody could recommend an authentic source in this regard.
 
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Appreciated.
 

1. What causes Down syndrome?

Down syndrome is caused by an extra copy of chromosome 21, which occurs during the formation of reproductive cells (eggs and sperm) or during early fetal development. This extra copy of genetic material can lead to physical and developmental differences.

2. Can a mother's age affect the chances of having a child with Down syndrome?

Yes, the risk of having a child with Down syndrome increases with maternal age. This is because as a woman gets older, there is a higher chance of errors occurring during the formation of reproductive cells.

3. Is there a way to prevent Down syndrome?

Currently, there is no known way to prevent Down syndrome. It is a genetic condition that occurs by chance and cannot be prevented.

4. Are there any environmental factors that can increase the chances of having a child with Down syndrome?

No, Down syndrome is not caused by environmental factors. It is a genetic condition that occurs randomly and is not influenced by a mother's diet, lifestyle, or exposure to toxins.

5. Can a mother's health during pregnancy affect the development of Down syndrome in her child?

No, there is no evidence to suggest that a mother's health during pregnancy has any impact on the development of Down syndrome in her child. It is a genetic condition that occurs before or during conception.

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