Question about designing therapies for HIV

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In summary, the conversation discusses the possibility of creating a virus that can kill only HIV-infected cells while replicating at a faster rate than HIV. The potential challenges and ethical concerns of such a virus are also mentioned, as well as the existence of similar viruses in nature. The conversation also mentions a blog post discussing a potential rival for HIV.
  • #1
r731
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As far as I know, HIV replicates itself at an exponential rate in a base b. For simplicity, let b = 2.

For example, if one cell is infected, then HIV makes one copy of itself (since b = 2). And the cell dies to infect two new cells. These two new cells die to infect four new cells and so on...

My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

If HIV replicates itself in base 2 but the viral medicine replicates itself in base 6, then it's apparent that the viral medicine spreads much faster than HIV.
 
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  • #2
r731 said:
My question is whether it is possible to create a virus that immediately kills only HIV-infected cell but replicates at an exponential rate higher than that of HIV's.

Wouldn't this new virus be even worse if it's infecting your body's cells to replicate at a faster rate than HIV?
 
  • #3
This is in fact a relatively new area of interest in virology, we still have such limited information about most viruses and they inhabit a surprisingly complex world. I don't know about creating one, it appears there may already be some potential candidates in nature. I suspect that the main problems will be similar to the ones seen in attempts to use bacteriophages, our own immune system might help protect the pathogen. You might find this interesting.
https://varuncnmicro.blogspot.com/2012/11/a-rival-for-hiv.html
 

1. How do antiretroviral therapies work to treat HIV?

Antiretroviral therapies work by targeting different stages of the HIV life cycle, preventing the virus from replicating and reducing the amount of virus in the body. They can also help to strengthen the immune system and prevent opportunistic infections.

2. What are the main challenges in designing effective therapies for HIV?

One of the main challenges in designing therapies for HIV is the virus's ability to mutate and develop resistance to medications. This requires constant monitoring and development of new drugs. Another challenge is ensuring access to these therapies for all individuals, as well as managing potential side effects and drug interactions.

3. How do scientists determine which drugs to include in combination therapy for HIV?

Scientists use a variety of methods, including laboratory testing and clinical trials, to determine which drugs are most effective at targeting different stages of the HIV life cycle. They also consider factors such as drug interactions, potential side effects, and accessibility.

4. Can HIV be cured with current therapies?

While current therapies can effectively control the virus and allow individuals to live long, healthy lives, there is currently no cure for HIV. However, ongoing research and advancements in treatment may one day lead to a cure.

5. How do scientists ensure that therapies for HIV are safe and effective?

Before a new therapy is approved for use, it must go through rigorous testing and clinical trials to ensure its safety and effectiveness. Scientists also continue to monitor and study the long-term effects of these therapies to make improvements and ensure their continued safety.

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