Telomeres of neurons: Do they also become more short?

In summary, telomeres are repetitive DNA sequences found at the ends of chromosomes that act as protective caps. They naturally become shorter with age and have been linked to age-related diseases. Telomeres have also been found in neurons, but they are shorter and less well-studied. Factors such as stress and inflammation can accelerate the shortening of telomeres in neurons, while healthy lifestyle habits may slow down the process. While there is no direct evidence, there is a correlation between shorter telomeres in neurons and the development of neurodegenerative diseases. Further research is needed to fully understand the role of telomeres in these diseases.
  • #1
limarodessa
51
0
Hello all! During mitosis the telomeres reduced. But neurons do not divide during postnatal period (neural stem cells are exclusion). So - does Hayflick limit exist for neurons?
Thanks
 
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  • #2
Sure... the Hayflick limit is just the number of times a cell will divide. Most terminally differentiated neuronal cells would simply have zero divisions.

Also, note that telomere length is not the only factor determining the number of replications.
 

1. What are telomeres and why are they important?

Telomeres are repetitive DNA sequences found at the ends of chromosomes. They act as protective caps to prevent the loss of important genetic information during cell division. As we age, telomeres naturally become shorter and this has been linked to various age-related diseases.

2. Do telomeres also exist in neurons?

Yes, telomeres have been found in neurons. However, they are shorter and less well-studied compared to telomeres in other cell types.

3. Can telomeres in neurons become shorter?

Yes, telomeres in neurons can become shorter with age. This is due to the limited ability of neurons to regenerate and the natural process of cell division.

4. Are there any factors that can affect the shortening of telomeres in neurons?

Research has shown that stress, inflammation, and oxidative damage can accelerate the shortening of telomeres in neurons. Conversely, healthy lifestyle habits such as exercise and a balanced diet may help slow down the shortening process.

5. Is there any evidence that shortening of telomeres in neurons contributes to neurodegenerative diseases?

While there is no direct evidence, studies have shown a correlation between shorter telomeres in neurons and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's. Further research is needed to fully understand the role of telomeres in these diseases.

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