- #1
Matt204823545
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- TL;DR Summary
- I don't understand when people explain it.
So I'm studying the MAPK pathway and Erk (MAPK) activates IEGs (Immediate Early response Genes) such as Myc, Fos and Jun. What are IEGs?
I was told:
IEGs:
- expressed at the mRNA level (what does this mean? what's a "level"? what does "expressed" mean?)
- and hence don't require protein synthesis (what does this mean? why is this special? what is protein synthesis?)
- Myc is an IEG and a transcription factor that activates expression of late response genes (what's the difference between late response and IEG?)
Here's the 2 minute lecture that I'm referring to:
This is from my textbook:
I was told:
IEGs:
- expressed at the mRNA level (what does this mean? what's a "level"? what does "expressed" mean?)
- and hence don't require protein synthesis (what does this mean? why is this special? what is protein synthesis?)
- Myc is an IEG and a transcription factor that activates expression of late response genes (what's the difference between late response and IEG?)
Here's the 2 minute lecture that I'm referring to:
This is from my textbook:
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