- #1
sameeralord
- 662
- 3
Hello guys,
This is what wiki says,
Now why do they say it is amplified by chronically low insulin levels. Hormone sensitive lipase which breaks down Triglycerides is inhibited by insulin. Lipoprotein lipase which breaks down Triglycerides is activated by insulin. Since insulin level is low in this case, how does low insulin levels increase TG level, it should decrease it right.
The only way I could see TG increasing is excess Acetyl CoA turned TG. Your help would be much appreciated. Thanks
This is what wiki says,
Hypertriglyceridemia resulting from amplified triglyceride production is another indirect effect of impaired gluconeogenesis, amplified by chronically low insulin levels. During fasting, the normal conversion of triglycerides to free fatty acids, ketones, and ultimately glucose is impaired. Triglyceride levels in GSD I can reach several times normal and serve as a clinical index of "metabolic control".
Now why do they say it is amplified by chronically low insulin levels. Hormone sensitive lipase which breaks down Triglycerides is inhibited by insulin. Lipoprotein lipase which breaks down Triglycerides is activated by insulin. Since insulin level is low in this case, how does low insulin levels increase TG level, it should decrease it right.
The only way I could see TG increasing is excess Acetyl CoA turned TG. Your help would be much appreciated. Thanks