Even in SR the points on the "blank" manifold do not correspond to events.
http://arxiv.org/abs/0802.4345
"From a General-Relativistic point of view, Minkowski space just models an empty spacetime, that is, a spacetime devoid of any material content. It is worth keeping in mind, that this was not Minkowski’s view. Close to the beginning of Raum und Zeit he stated: In order to not leave a yawning void, we wish to imagine that at every place and at every time something perceivable exists."
In GR, it is difficult (impossible?) to construct there are local gauge-invariant observables unless matter is present.
http://arxiv.org/abs/gr-qc/0110003
"If there is matter we can localize things with respect to the matter. For instance, we can consider GR interacting with four scalar matter fields. Assume that the configuration of the fields is sufficiently nondegenerate."
http://arxiv.org/abs/gr-qc/9404053
"We will refer to such gauge invariants as observables. ... Of course, these observables are not of the type with which we are familiar from, say, scalar field theory and they may be highly non-local. ... If the density ω is distributional, the resulting gauge invariant may be effectively local on M. A simple example of such an observable is the value of some scalar quantity at a point specified by an “intrinsic coordinate system.” For gravity coupled to a set of scalar fields"
http://arxiv.org/abs/gr-qc/9509026
"The use of material reference systems in general relativity has a long and noble history. Beginning with the systems of rods and clocks conceived by Einstein [1] and Hilbert [2], material systems have been used as a physical means of specifying events in spacetime and for addressing conceptual questions in classical gravity. ... The original systems of rigid rods and massless clocks discussed by Einstein and Hilbert represent unphysical idealizations. Since their time, attempts have been made to remedy this shortcoming by developing a more physically realistic description of the reference medium."