COVID Antibody from Common Cold reacts to COVID

AI Thread Summary
The discussion centers on a misleading post about a study regarding antibodies related to COVID-19 and common cold coronaviruses. The study indicates that while antibodies from patients infected with SARS-CoV-2 can cross-react with some common cold coronaviruses, there is no evidence that pre-existing antibodies from common cold infections react with SARS-CoV-2. The authors of the study speculate that the cross-reacting antibodies may arise from memory B-cells developed after prior infections, but this remains a hypothesis that requires further research. The key takeaway is that antibodies from common cold infections do not provide immunity or protection against COVID-19, contradicting the initial claims in the misleading post.
Tom.G
Science Advisor
Gold Member
Messages
5,661
Reaction score
4,504
THIS POST TITLE IS MISLEADING. I paraphrased/lifted from the jpost. com article but did not read the research article. @Ygggdrasil graciously points out the error in post #3 below. Thanks!

The study found that the antibody in question reacts not only to SARS-CoV-2, which causes COVID-19, but also SARS-CoV-1, which causes Severe Acute Respiratory Syndrome (SARS).

https://www.jpost.com/health-science/study-identifies-antibody-from-common-cold-infection-that-reacts-to-covid-669579

Open access research article:
https://www.nature.com/articles/s41467-021-23074-3

Cheers,
Tom
 
Last edited:
Biology news on Phys.org
Here's some background:

There are 3 Coronavirus infections that were most decidedly not "common":
SARS (2003), MERS (2012), and COVID-19 (2019).

According to this May 2020 NIH Article:
An estimated 20 to 30 per cent of common colds are caused by four coronaviruses
Those four are:
HCoV-OC43
HCoV-HKU1
HCoV-229E
HCoV-NL53
 
That's not an accurate summary of the article. The article looked at serum samples collected pre-pandemic and see that none of the samples contain antibodies that cross-react with SARS-CoV-2 even though they contain high titers of antibodies that react with the common cold coronaviruses:
1622407956740.png

https://www.nature.com/articles/s41467-021-23074-3

Indeed, as the authors note in the paper:
In sera from our pre-pandemic cohort, we found no evidence of pre-existing SARS-CoV-2 S-protein reactive antibodies that resulted from endemic HCoV infections, consistent with other studies41,42.

The broadly cross-reacting antibody identified in the study was isolated from patients who had been infected with SARS-CoV-2. The fact that some of the anti-SARS-CoV-2 antibodies they isolated cross-react with the common cold beta-coronaviruses (HKU1 and OC43) lead them to speculate that these antibodies originated from the maturation of memory B-cells left over previous common cold Coronavirus infections. However, the authors note that this hypothesis is speculative:

In general, it should be noted that although our study provides evidence for a recall of cross-reactive Abs upon SARS-CoV-2 infection, the most definitive demonstration of the origins of cross-reactive Ab responses would come from longitudinal human studies of donors before and after SARS-CoV-2 infection.

So, no, antibodies from the common cold do not react with or protect from COVID-19. Rather, it is possible (but not definitively shown) that memory B-cells from previous common cold infections could provide the source of some antibodies against COVID-19.
 
https://www.nhs.uk/mental-health/conditions/body-dysmorphia/ Most people have some mild apprehension about their body, such as one thinks their nose is too big, hair too straight or curvy. At the extreme, cases such as this, are difficult to completely understand. https://www.msn.com/en-ca/health/other/why-would-someone-want-to-amputate-healthy-limbs/ar-AA1MrQK7?ocid=msedgntp&cvid=68ce4014b1fe4953b0b4bd22ef471ab9&ei=78 they feel like they're an amputee in the body of a regular person "For...
Thread 'Did they discover another descendant of homo erectus?'
The study provides critical new insights into the African Humid Period, a time between 14,500 and 5,000 years ago when the Sahara desert was a green savanna, rich in water bodies that facilitated human habitation and the spread of pastoralism. Later aridification turned this region into the world's largest desert. Due to the extreme aridity of the region today, DNA preservation is poor, making this pioneering ancient DNA study all the more significant. Genomic analyses reveal that the...
Back
Top