Any contraindications of inhaling pure O2?

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Discussion Overview

The discussion revolves around the potential contraindications and effects of inhaling pure oxygen (O2). Participants explore various aspects including physiological responses, risks of oxygen toxicity, and historical contexts, with references to specific scenarios such as mountain climbing and medical applications.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants suggest that higher concentrations of O2 could enhance human performance, particularly in high-altitude scenarios, but acknowledge the challenges of returning to normal air concentrations.
  • One participant references a study indicating that COPD may be a contraindication for 100% O2 delivery, though EMS protocols sometimes still recommend it in acute situations.
  • Another participant raises concerns about disorientation and pH imbalance due to CO2 displacement when breathing pure O2 for extended periods.
  • Oxygen toxicity is mentioned as a known risk, with references to its effects on the central nervous system and the importance of maintaining safe partial pressures.
  • One participant shares anecdotal evidence from welding school about the dizziness caused by inhaling pure oxygen and the potential for respiratory suppression due to the lack of CO2.
  • A historical note is made regarding NASA's plans for astronauts to breathe pure oxygen during the Apollo missions, highlighting the risks involved in such practices.

Areas of Agreement / Disagreement

Participants express a range of views on the effects and risks of inhaling pure oxygen, with no consensus reached on the overall safety or benefits. Multiple competing perspectives remain regarding its physiological impacts and contraindications.

Contextual Notes

Limitations include varying definitions of safe oxygen levels, the dependence on individual health conditions, and the context of use (e.g., medical vs. recreational). Unresolved questions about the long-term effects of pure oxygen inhalation are also present.

Weissritter
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As cited in any biology book, humans require oxygen for functioning properly. Using non-experimental-based results, and plain logic, an air with higher concentration of O2 gives any human a better performance. When mountain climbers climb mountains, they slowly require more oxygen. If they don't get it, their capabilities go down. If any person living in a high city goes to the sea, he/she could run faster, higher or anything similar because a slight rise of the quantity of oxygen. This only tells me that pure oxygen could have a 'boost' on animals, incluiding humans.
But this link here jumps objecting.
http://www.medicalnewstoday.com/releases/72299.php
So I wanted to ask a scientific community about it. Whaddya think, or know?
And yes, I'm aware that, in a scenario that there is not a single problem, I'd have a hard time getting back into an average 21% ox'd air.
 
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Weissritter said:
As cited in any biology book, humans require oxygen for functioning properly. Using non-experimental-based results, and plain logic, an air with higher concentration of O2 gives any human a better performance. When mountain climbers climb mountains, they slowly require more oxygen. If they don't get it, their capabilities go down. If any person living in a high city goes to the sea, he/she could run faster, higher or anything similar because a slight rise of the quantity of oxygen. This only tells me that pure oxygen could have a 'boost' on animals, incluiding humans.
But this link here jumps objecting.
http://www.medicalnewstoday.com/releases/72299.php
So I wanted to ask a scientific community about it. Whaddya think, or know?
And yes, I'm aware that, in a scenario that there is not a single problem, I'd have a hard time getting back into an average 21% ox'd air.

This doesn't address the study you found and the mechanism that they are studying, but COPD is sometimes considered a contraindication for 100% O2 delivery:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564043/

However, as that article points out, often our field EMS protocols still call out 100% O2 for COPD patients in respiratory distress -- the benefits of the O2 can outweigh the worries about the hypoxic drive, at least in the temporary pre-hospital EMS transport context.
 
I've wondered about this as well- it's possible to become disoriented when breathing pure O2 for an extended time (a few minutes or so). The best answer I've heard is that the O2 will over time displace CO2, which leads to a pH imbalance.
 
Oxygen toxicity has been known for a 100 years or so.
http://en.wikipedia.org/wiki/Oxygen_toxicity


and from
http://en.wikipedia.org/wiki/Scuba_diving
Quote:

Oxygen
Oxygen toxicity occurs when oxygen in the body exceeds a safe partial pressure (PPO2).[2] In extreme cases it affects the central nervous system and causes a seizure, which can result in the diver spitting out his regulator and drowning. While the exact limit is idiomatic, it is generally recognized that Oxygen toxicity is preventable if one never exceeds an oxygen partial pressure of 1.4 bar.[21] For deep dives—generally past 180 feet (55 m), divers use "hypoxic blends" containing a lower percentage of oxygen than atmospheric air. For more information, see oxygen toxicity.

unquote.
 
In welding school they taught us that sniffing the pure oxygen from the welding oxygen bottle will send you dizzy. However, they also cautioned that it can kill, by suppressing breathing. The reason is that breathing is a response to CO2 concentration. So medical oxygen has a small amount of CO2 in it to stimulate breathing.
 
Remember that NASA had plans for the lunar astronauts to breath pure oxygen in the Apollo spacecraft on the way to the Moon, a week long (or more) time period. Of course, that didn't work out so well since Apollo 1 burned up during a test, killing three astronauts.
 

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