Title says it all. If not, is it possible that in the future we will have a dog who's DNA is so different than their original ancestors, the wolves, that they wouldn't be able to mate with them? Also, another related question. What does it take to be reproductively compatible? Does the DNA just have to be similar. The chimp's DNA is something like 1.6% different from humans, but that is too big of a difference to reproduce. Is there a maximum percent difference required in order to be sexually compatible?