To apply Newton's second law effectively, all velocities in a system should be expressed relative to the lab frame, which is an inertial reference frame. While velocity does not explicitly appear in Newton's second law, it is crucial in specific applications like rocket problems, where momentum change is calculated. The equation for thrust involves both mass flow rate and velocity, highlighting the relationship between momentum and force. Additionally, when determining force over time, the change in momentum is directly linked to changes in velocity. Understanding these concepts is essential for accurately solving physics problems involving motion.