Calculating core losses in a toroid core involves referencing the manufacturer's data sheet and application notes for accurate computations. The discussion highlights the need for detailed information about the transformer's specifications, including frequency range, voltages, currents, and construction details, to provide effective assistance. Concerns are raised regarding the safety of designing a high-voltage step-up transformer, especially for a beginner. The importance of experience when working with high voltages is emphasized, along with the necessity for safety precautions. Comprehensive details about the project are essential for further guidance.