Can all the multiplexers work for any number of variables given?

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Multiplexers can be designed to handle any number of input variables, but practical limitations arise from the number of terminals available on the chip. A 16:1 multiplexer can be configured for two input variables, A and B, although multiplexers are typically available as 1-bit slices, with options for 2, 3, and 4-bit wide slices. The efficiency of using wider slices is minimal, as the primary savings come from address decode logic. For implementing wider parallel bus multiplexers, tri-state, open collector, or open-drain outputs are recommended.

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Can all the multiplexers work for any number of variables given? For example can I make a 16:1 multiplexer for 2 variables inputs, A and B?
 
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Any number of inputs are possible. Usually the limit is the number of terminals on the chip.

Multiplexers are usually available as a 1 bit slice, but 2, 3 and 4 bit wide slices are also available. There is not much saving gained by putting wider slices in a single chip since only the address decode logic is saved.

Tri-state, open collector, or open-drain outputs (called wired-OR) are preferred to implement wider parallel bus multiplexers.
https://en.wikipedia.org/wiki/Three-state_logic
https://en.wikipedia.org/wiki/Open_collector#Applications_of_open-collector_devices
 

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