The discussion centers on proving that if either 2n-1 or 2n+1 is prime for n > 2, then the other must not be prime. Participants suggest starting with a base case, such as n = 3, where 2^3-1 equals 7 (prime) and 2^3+1 equals 9 (not prime). The approach involves using mathematical induction, assuming the statement holds for a particular n and then proving it for n + 1. There is also mention of specific conditions under which 2^n-1 and 2^n+1 can be prime, particularly focusing on odd and even values of n. The discussion emphasizes the need for a structured proof using induction to establish the relationship between the two expressions.