Absolutely. Look at the graph below, from
this recent paper. The blue lines are the predicted abundances of(from the top) He4, He3, D, and Li7. as a function of the baryon to photon ratio (η). The green bands are the measured abundances (with error bars), and the gray line is the baryon to photon ratio measured by Planck(also with error bars). He4, He3, and D all agree beautifully. Li7 doesn't agree, but that's another story. Notice that the measured Li7 abundance is only 10^-10 of H, so these are very difficult measurements. Setting the Li7 aside, you can see that if you changed the number of baryons by even a factor of 2, things wouldn't even be close. A factor of 5 is off the chart, but the discrepancies would be huge.
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