kadiot
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There's bound to be huge recession; many will be poorer than when this pandemic began; 2008 recession will look like peanuts.
zoki85 said:I hope not...
kadiot said:The Philippine government is planning to start the "mass testing" of COVID-19 Person Under Investigation (PUI) and Person Under Monitoring (PUM) on April 14, 2020.
1. Mass testing is not testing everyone. It is “risk-based” testing. Basically, you test people in increasing circles of risk: test the PUI, then the close contacts, then the community. It is not a shotgun approach because no country can test every single citizen for COVID-19. So we need to figure out our priorities for testing, and WHAT TEST to use. You CAN’T test 100M people, but you can test the MOST AT RISK.
2. Understand the limitations of testing. No TEST is 100% accurate. There are trade-offs. The probability that a test is positive when the disease is REALLY present is called the SENSITIVITY. The probability that a negative test actually means the disease is REALLY NOT there is called the SPECIFICITY.
3. A good sensitivity means that a test is able to detect disease MOST of the time if it is PRESENT in a patient. Having a negative test when the disease is PRESENT is called a FALSE NEGATIVE. In other words, the test failed to detect a sick person.
4. A good specificity means that a test is NEGATIVE MOST of the time if there is NO DISEASE in a patient. Having a positive test when the disease is ABSENT is called a FALSE POSITIVE.
5. FALSE NEGATIVES are harmful because you say that someone is COVID-19-free when he actually has COVID-19 so that patient will be free to spread the disease.
6. FALSE POSITIVES are harmful because you will put a patient WITHOUT COVID-19 in the hospital, possibly with REAL COVID-19 patients such that the patient can get COVID, or be isolated needlessly.
7. So how good are the tests? There are two tests we can use for COVID-19 – RT-PCR and antibody tests.
8. RT-PCR is considered the best test for diagnosing ONGOING COVID-19 infection. PCR itself is very sensitive and specific, >90% for both. HOWEVER, the TYPE of specimen and the stage of disease (how many days with symptoms) can affect how often a test is positive. So for RT-PCR, using a nasopharyngeal swab in a patient WITH disease, the probability of getting a positive test is only 63%. So you will actually MISS 37% of cases. This is why we can do a REPEAT test after 48 hours in a patient who is getting sicker of what looks like COVID, but was NEGATIVE on the first test. The DANGER of RT-PCR is a FALSE NEGATIVE and you can end up clearing someone who actually has COVID-19. This can happen in UP TO 1/3 OF PATIENTS so its not a perfect test.
9. RT-PCR is also a highly technical process that not only involves having the right machine and kits, BUT also the proper SAFETY INFRASTRUCTURE like a BSL2 laboratory. Many labs and hospitals HAVE RT-PCR machines but they do not have the biosafety infrastructure.
10. Antibody tests include PRNT (Plaque reduction neutralization test, the gold standard), ELISA (enzyme linked immunosorbent assay) and lateral flow IgM/IgG. The first two are LABORATORY based assays and the last is a point of care rapid diagnostic test (POC-RDT).
11. As much as we would like to use rapid lateral flow assays (IgM/IgG) because of convenience, NONE of the lateral flow assays have used the industry standard PRNT assay as a gold standard. In other words, we have NO IDEA how good they are despite their claimed sensitivity and specificity. The biggest danger is that because it takes 5 to 10 days to make IgM antibody, the test has a high FALSE NEGATIVE rate in those who just started having symptoms. And so you will get a FALSE SENSE OF SECURITY and end up passing the virus to other people and your family members.
12. The OTHER problem with the lateral flow IgM/IgG is that there are other HUMAN CORONAVIRUSES that cause the common cold, and some antibodies against these viruses may CROSS-REACT with the test, giving you a FALSE POSITIVE, which is bad for the reasons stated.
The BOTTOM LINE is NONE OF THESE TESTS ARE PERFECT. FAR from it. Tests INFORM your response, but they still need to be INTERPRETED in the right context.
To some lay persons like myself, we think that a positive is a positive, and a negative is a negative. To clinicians and scientists, they come with HUGE caveats in management. There are times they WILL NOT believe a test result because it is NOT CONSISTENT with the patient’s clinical picture. If we let ourselves be mislead by a test result without USING OUR BRAIN, people will DIE. And this also holds for doing public health strategies and mass testing.
bhobba said:If I remember correctly in China only 1% actually ever got it.
bhobba said:If I remember correctly in China only 1% actually ever got it.
Looks like asymptomatic cases will be wreaking havocchemisttree said:That story is far from finished.
“Some venues that had reopened were told by the government to close yet again.”
kadiot said:Sweden's no lockdown policy is based on the recommendation of the country's leading epidemiologist. The strategy is totally opposed to what the rest of the world is doing. Let's see how this experiment turns out.
DrClaude said:While there is no lockdown, there are many recommendations to limit contact and people are following them.
atyy said:Well, I believe South Korea also has no lockdown, and they've been successful so far.
I just looked at the Reuters news site and there was a brand new article about Sweden's liberal strategy which is being questioned domestically:DennisN said:Yes. It seems we are quite compliant in Sweden, both judging from the news and from my own experience.
Article said:But Sweden’s liberal approach, which aims to minimise disruption to social and economic life, is coming under fire as the epidemic spreads in the capital.
“We don’t have a choice, we have to close Stockholm right now,” Cecilia Soderberg-Naucler, Professor of Microbial Pathogenesis at the Karolinska Institute, told Reuters.
She is one of around 2,300 academics who signed an open letter to the government at the end of last month calling for tougher measures to protect the healthcare system.
“We must establish control over the situation, we cannot head into a situation where we get complete chaos. No one has tried this route, so why should we test it first in Sweden, without informed consent?” she said.
...
The public face of Sweden’s pandemic fight, Health Agency Chief Epidemiologist Anders Tegnell, only months ago a little known civil servant but now rivalling the prime minister for publicity, has questioned how effectively lockdowns can be enforced over time.
“It is important to have a policy that can be sustained over a longer period, meaning staying home if you are sick, which is our message,” said Tegnell, who has received both threats and fan mail over the country’s handling of the crisis.
“Locking people up at home won’t work in the longer term,” he said. “Sooner or later people are going to go out anyway.”
I wouldn't be surprised if Stockholm was put under lockdown in the coming days. Maybe even Malmö and Göteborg, looking at the current map of known cases:DennisN said:I just looked at the Reuters news site and there was a brand new article about Sweden's liberal strategy which is being questioned domestically:
Sweden's liberal pandemic strategy questioned as Stockholm death toll mounts (Reuters, April 3 2020)
Working draft from the inter-agency task force on emerging infectious diseases in the Philippines. I'll post here the final and official paper once it's done,atyy said:Where did you get this from? It looked correct when I gave it a quick read.
My take on this and the broader issue...kadiot said:Researchers from the University of Nebraska Medical Centre and the National Strategic Research Institute at the University of Nebraska took air samples from 11 rooms where 13 confirmed cases were being treated.
As well as finding genetic material from the Coronavirus on lavatories and on everyday items, 63.2 per cent of air samples taken inside the rooms and 66.7 per cent of those taken outside also showed traces.
In his books "The Black Swan" and "Antifragile", Nassim Nicholas Taleb argues that the usual measures of risk are increasingly inadequate in the modern world. They deal only with a certain class of risks but not with events like the financial crisis in 2008 or the current Coronavirus crisis which are arguably much more influencial. He suggests a different approach to risk management based on identifying a specific class of big risks ("systemic" and "fat-tailed") and being more cautious towards them. In line with this, he co-authored a call to action regarding the current crisis in late January. I find his line of thinking quite interesting.russ_watters said:History may judge South Korea's reaction "right" and everyone else's "wrong", but when an awful lot of people independently come to the "wrong" conclusion, I think you have to accept that reality at face value: under most systems of logic, political philosophy, risk tolerance, institutional inertia, etc. the data did not support an aggressive response.
peanut said:Saw this University of Cambridge published diagram and eventually found the original paper.
They have kitchens. Also, the building staff don't all live together in tiny quarters.chemisttree said:How are the multistory apartment buildings in NYC different than the cruise ships being refused dockage in Florida?
The passengers of those land-bound ships can freely come and go.
https://www.bloomberg.com/graphics/2020-united-states-coronavirus-outbreak/
kith said:In his books "The Black Swan" and "Antifragile", Nassim Nicholas Taleb argues that the usual measures of risk are increasingly inadequate in the modern world. They deal only with a certain class of risks but not with events like the financial crisis in 2008 or the current Coronavirus crisis which are arguably much more influencial. He suggests a different approach to risk management based on identifying a specific class of big risks ("systemic" and "fat-tailed") and being more cautious towards them. In line with this, he co-authored a call to action regarding the current crisis in late January. I find his line of thinking quite interesting.
kith said:In his books "The Black Swan" and "Antifragile", Nassim Nicholas Taleb argues that the usual measures of risk are increasingly inadequate in the modern world. They deal only with a certain class of risks but not with events like the financial crisis in 2008 or the current Coronavirus crisis which are arguably much more influencial. He suggests a different approach to risk management based on identifying a specific class of big risks ("systemic" and "fat-tailed") and being more cautious towards them. In line with this, he co-authored a call to action regarding the current crisis in late January. I find his line of thinking quite interesting.
kith said:In his books "The Black Swan" and "Antifragile", Nassim Nicholas Taleb argues that the usual measures of risk are increasingly inadequate in the modern world.
It'll take me some time to dig into those, but its a subject that interests me, so I will. First impression is I like the overall idea, but at the same time the tweets show a theatrical flair that I don't really like. Tweets are like that, by nature though.kith said:In his books "The Black Swan" and "Antifragile", Nassim Nicholas Taleb argues that the usual measures of risk are increasingly inadequate in the modern world. They deal only with a certain class of risks but not with events like the financial crisis in 2008 or the current Coronavirus crisis which are arguably much more influencial. He suggests a different approach to risk management based on identifying a specific class of big risks ("systemic" and "fat-tailed") and being more cautious towards them. In line with this, he co-authored a call to action regarding the current crisis in late January. I find his line of thinking quite interesting.
atyy said:Well, I believe South Korea also has no lockdown, and they've been successful so far. I think the two successful cases so far are China and South Korea. China's problem was bigger because the outbreak started there and they mishandled things initially. Nonetheless South Korea also handled a great challenge. So it seems that depending on how out of control things are, both countries show the range of potentially successful policies.
BillTre said:My understanding of the S. Korea situation is that they were strongly affected by the events of their SARS infections years ago. This lead them to:
The US medical experts are not stupid and could also learn from SARS...
- get ready for another epidemic
- take things seriously when the situation looked like a potential epidemic
I guess this would be in the set of things you are calling "systems of logic, political philosophy, risk tolerance, institutional inertia, etc.".
I'm OK with that if you realize that it has a lot to do with the political philosophy and their lack of foresight and consideration of effects on people as a population rather than as economic entities.
To many medically trained people (in the same country), the available data did support an (more) aggressive response.
I don't think it is something that should be forgotten since they will be doing this over and over again if not called out on it and similar things.
Yes, I'll go with a rare and unique combination of factors. In particular, the pain of experience is a powerful motivator, which they uniquely had. I expect they have many of the same political and social motives all humans have; they just got overridden.mfb said:South Korea is a country that listened closely to experts.
Too many other governments were more concerned about their public image, about their re-election chances, about selling their private stocks before taking public action, and similar things, while too many people in these countries were more worried about their holidays than about the pandemic.
The reaction of South Korea made perfectly sense. It's just rare to see governments and most people listening to experts.
That graphic is hard to read or maybe just accept. It seems to be saying the most of northeast quadrant of the US was fully quarantined (zero travel), even most of PA and MD which didn't have orders to do so. That would be surprisingly effective.BillTre said:Here is a NY Times article on where and when travel restrictions were imposed in the US and what were its effects on distances traveled (based on cell phones).
Several maps and graphs.
Stephen Tashi said:This site shows data about deaths in the Europe from all causes: https://www.euromomo.eu/index.html
Anyone know of an online source for similar data about regions in the USA?
russ_watters said:Yes, I'll go with a rare and unique combination of factors. In particular, the pain of experience is a powerful motivator, which they uniquely had. I expect they have many of the same political and social motives all humans have; they just got overridden.
I read Malcom Gladwell's "Outliers" recently, which is a book about the luck and cultural influences on success and failure. It has a chapter on a rash of airline crashes in South Korea a few decades ago. The reason? Their airline crews didn't work well together due to a cultural trait called (I think) superior-subordinate distance and the related respect for authority trait. S. Korea is one of the most, if not the most socially hierarchical societies on the planet (on the opposite end of those scales: the USA). So the first officer on an airliner would just sit with his mouth shut while his captain crashed the plane, instead of speaking-up about a problem he noticed that the captain didn't. Sometimes subordinating yourself to authority has a downside, but in the case of this pandemic it has its upside.
These traits, primed by the pain of experience likely had South Korea uniquely primed to listen to authority both from epidemiologists and government enforcers of quarantines.
It's in India (a.k.a. the worst case scenario), not in the USA.Vanadium 50 said:Their forecast doesn't seem to match the data.
russ_watters said:Specifically, the one about Italy "lowering" vs "risking" the economy; I think it is both: they are lowering the economy on purpose (as is everyone), but by an unplanned/unclear amount and with very unclear future impact. The unclear future impact of their actions is risk. In the first few paragraphs the first paper, he's saying that the burden of proof is on the people creating the risk and the default position should be to not take an action if you have a poor grasp of its outcome/risk.
Kids are dumb, but if you lock them inside, they have fewer opportunities to kill themselves by doing dumb things.Vanadium 50 said:Very interesting. Onhttps://www.euromomo.eu/outputs/cumulated.html, the clearest trend, by far, is the reduction in deaths in the 5-14 bracket. Any explanation why?
Last summer, Paris riots? Strikes?Vanadium 50 said:5-14 bracket. Any explanation why?
Vanadium 50 said:Their forecast doesn't seem to match the data.
Which part are you referring to?bhobba said:They do not seem to.
Thanks
Bill
kadiot said:Which part are you referring to?
On one side we have millions of deaths plus some unclear but still huge economic damage.russ_watters said:Specifically, the one about Italy "lowering" vs "risking" the economy; I think it is both: they are lowering the economy on purpose (as is everyone), but by an unplanned/unclear amount and with very unclear future impact. The unclear future impact of their actions is risk. In the first few paragraphs the first paper, he's saying that the burden of proof is on the people creating the risk and the default position should be to not take an action if you have a poor grasp of its outcome/risk. That's the opposite of what we're doing to the economy and the big conundrum here: the risk of deaths from doing nothing seems to be easier to predict than the risk to the economy of a prolonged shutdown. The chosen path has two main consequences, with opposite risk profiles.
It's a decrease in Summer 2019. There is no 2020 data on that website.russ_watters said:Kids are dumb, but if you lock them inside, they have fewer opportunities to kill themselves by doing dumb things.
...also, they can't die in their parents' cars.
Lock down for 49 days is ideal situation. No breakage in between. Benefits are more than anything. Corona will be eliminated.bhobba said:The widely publicised initial Cambridge models now seen far too pessimistic. To be fair I think the assumptions that went into them did not take into account the strong measures most countries are taking in light of the spread of the virus.
Thanks
Bill
kadiot said:It's in India (a.k.a. the worst case scenario), not in the USA.
Figure 4 is with mitigatory social distancing.Vanadium 50 said:I can read, thank you.
Which is the data it doesn't match. Figure 4 shows a prediction of 250 infected individuals today. Instead India has 2900.
You (and peanut) could have checked this `before posting. Maybe even should have.
Sorry I am not as smart as you. Don't worry I will refrain from posting here. Thank you everyone.Vanadium 50 said:@mfb, there may be something of value in that paper, but the authors sure don't ,make it easy to find, especially if to interpret it you have to assume that the plot labeling is wrong.
You're vastly underestimating the "known" and totally ignoring the "unknown"/potential impact (and left the potential death toll very vague), but sure, if we use that characterization it makes the decision easy.mfb said:On one side we have millions of deaths plus some unclear but still huge economic damage.
On the other side we have ... millions of additional people needing social security for a while? Yeah, we won't have a good estimate for how many and for how long. But it's a really easy decision.
Well that isn't true. The containment efforts have been very uneven. Here's what a Swedish immunologist has to say about the lack of a lockdown there: "The government thinks they can’t stop it, so they’ve decided to let people die."So easy that it's made everywhere.
Oops!The earlier that decision is made the smaller the impact of it.It's a decrease in Summer 2019. There is no 2020 data on that website.
russ_watters said:Now, sure, maybe it's still worth it to make that decision, but I don't agree with others who say the propaganda value in scaring everyone with unrealistic death predictions while ignoring the economic impact is a good thing.
I think it is the number of infections. Their model appears to assume the effect of a lockdown kicks in in less than a day, anyone who is infected is symptomatic, individuals who know they're infected reduce contacts with others, and those contacts are only within households.mfb said:I'm not sure what these numbers are supposed to be. Clearly not the total number of infections, as that can't drop at the day a lockdown starts.
Although I don't remember taking advantage of it, I seem to recall that credit card, mortgage, and auto-loan companies I dealt with offered payment "holidays". Basically, they offered to let me skip an entire months payment, charge me only interest, and I would have ended up paying very little "noticeable" extra in the future.anorlunda said:...
When the mortgage loan forbearance period is over, the lenders have the right to demand all back payments be caught up in one lump payment. Few have that money, so what happens then?
...
OmCheeto said:"mean spirited" mortgage companies
I don't know what a "sensible person" is, but we had considerable discussion a few weeks ago about the Imperial College report that predicted 2.4 million deaths in the US (.5M in the UK) if no containment efforts were undertaken. The predicted outcome was never a realistic possibility, but nevertheless the report is credited with having a significant impact on policy:atyy said:No sensible person is saying such a thing.
They are taking reactive actions to limit economic damage, yes, but I haven't seen any actual predictions of what that damage may or could be*. No equivalent of the 2.4 million deaths, for the economic impact.As far as I understand most countries are acting with the economy in mind, they are trying to save the economy. You may disagree with the calculations, but there is no intention to scare with unrealistic death predictions, and there is every intention to act for the best economic outcome.