The discussion centers on whether science can adequately answer "what is it" questions, particularly regarding fundamental concepts like electric charge, time, space, consciousness, and gravity. It suggests that while science typically focuses on "how" questions, it often relies on precise definitions to address "what" inquiries. However, some questions may be inherently unsatisfactory, as they delve into the essence of concepts that are difficult to define. The conversation highlights that science continually seeks answers, but there are limits to its current understanding, often encountering a "brick wall" at the frontier of knowledge. The playful exchange about the nature of a horse illustrates the complexity and sometimes absurdity of trying to encapsulate the essence of any entity.