An old Nook eReader is experiencing connectivity issues with a new laptop, failing to be recognized when plugged in via USB. The user reports that the device was previously functioning well with an older PC. Troubleshooting steps discussed include checking the Device Manager for changes upon connection, verifying the USB cable's condition, and ensuring that the Nook's software is up to date. Despite attempts to resolve the issue, including reinstalling USB drivers and trying different PCs, the Nook remains unrecognized. A common solution mentioned is to power cycle the Nook by turning it off and on, which has resolved similar issues for others. The discussion highlights that this problem is not uncommon among Nook users, with no definitive solution provided beyond the power cycling method.