Let be think how we could obtain three generations of a "decolored standard model" from the conjugate irreducible representations of E6, 27 + \bar 27.
First we decompose the 27 of E6 into some 15+12 split, to allow for an -arbitrary- B and L quantum number. The most obvious start is to keep all the stuff together in single irreducibles, so the best bet is $SU(6) \times SU(2)$
$$
\begin{array}{|c||c|}
\hline
& SU(6) \times SU(2) \\
\hline
L & (\bar 6,2) \\
\hline
B & (15,1) \\
\hline
\end{array}
$$
Where, inspired by the sBootstrap, I have decided to consider that the 12 are leptons while the 15 are decoloured quarks.
Now let's try some path to assign hypercharges. Say, start with SU(6) branching to su3su3u1
$$
\begin{array}{|c |r ||c|}
\hline
& Y_1 & SU(3) \times SU(3) \times SU(2) \times U(1)_1\\
\hline
L & -1 &( \bar 3,1,2) \\
\hline
L & 1 &( 1, \bar 3,2) \\
\hline
B & 0 & (3,3,1) \\
\hline
B & 2 & (\bar 3,1,1) \\
\hline
B & -2& (1,\bar 3,1) \\
\hline
\end{array}
$$
Now one su3 down to su2u1:
$$
\begin{array}{|c |r |r ||c|}
\hline
& Y_1 & Y_2 & SU(3) \times SU(2)_T \times SU(2)_S \times U(1)_1 \times U(1)_2\\
\hline
L & -1 &0 &( \bar 3,1,2) \\
\hline
L & 1 & -1 &( 1, 2 ,2) \\
\hline
L & 1 &2 &( 1, 1 ,2) \\
\hline
B & 0 &1& (3,2,1) \\
\hline
B & 0 &-2& (3,1,1) \\
\hline
B & 2 &0& (\bar 3,1,1) \\
\hline
B & -2&-1& (1,2,1) \\
\hline
B & -2&2& (1,1,1) \\
\hline
\end{array}
$$
And here we could for instance do a charge assignment for the quark sector of the standard model, three generations.
$$
\begin{array}{|c |r |r ||c|| c | l }
\hline
& Y_1 & Y_2 & su3su2su2 & \frac 13 Y_1 + \frac 16 Y_2 + T \\
\hline
L & -1 &0 &( \bar 3,1,2) &-1/3 \\
\hline
L & 1 & -1 &( 1, 2 ,2)& +2/3 \\
& & && -1/3 \\
\hline
L & 1 &2 &( 1, 1 ,2) & +2/3 \\
\hline
B & 0 &1& (3,2,1) & +2/3 & u, c, t\\
& && & -1/3 & d,s,b\\
\hline
B & 0 &-2& (3,1,1) & - 1/3 & d,s,b\\
\hline
B & 2 &0& (\bar 3,1,1) & +2/3 & u,c,t\\
\hline
B & -2&-1& (1,2,1) & - 1/3\\
& && & - 4/3\\
\hline
B & -2&2& (1,1,1) & -1/3\\
\hline
\end{array}
$$
Which is midly satisfying but 1) it is not so right in the lepton sector, and 2) the three extra "quarks" have different charges; the sBootstrap predicted all the three to be Q=-4/3.
Surely the whole point is to try other assignments, even to keep breaking subgroups to get a finer set of hypercharges. But still let me note that the lepton sector can be arguably fixed by using
$$Y= -\frac 16 L + \frac 13 Y_1 + \frac 16 Y_2 + T $$
$$ Q= Y +S $$
as then we get 4 doublets with Y = -1/2 and 2 doublets having Y= +1/2, to be complemented with 4 doublets having Y= +1/2 and 2 doublets having Y = -1/2 coming from the $\bar {27}$ representation of E6. Still one needs to cope with the point of having two different isospin groups, but for a first try is nicely half-realistic.
Comparing with a typical E6 assignment of su3su2u1, this assignment has repurposed the extra coloured down-type quark as three generations of a lepton, and also moved some traditional extra leptons to the quark sector. This was justified by the first step in the branching. On other hand, 15+12 has not a obvious representation as a jordan matrix, or at least I am missing it.