Rewrite the last two equations as
$r^{2012}-u^{2012}=2012(t-s)$---(1)
$t^{2012}-s^{2012}=2012(r-u)$---(2)
Next, observe that $r=u$ holds iff $t=s$ holds. In that case, the last two equations are satisfied and the condition $rstu=1$ leads to a set of valid quadruples of the form $(r,\,s,\,t,\,u)=(k,\,\dfrac{1}{k},\,\dfrac{1}{k},\,k)$ for any $k>0$.
We now show that there are no other solutions. Assume that $r\ne u$ and $t\ne s$. Multiply the equation (1) by (2) we have
$(r^{2012}-u^{2012})(t^{2012}-s^{2012})=2012^2(t-s)(r-u)$
and divide the LHS by the RHS to get
$\dfrac{r^{2011}+\cdots+r^{2011-i}u^i+\cdots+u^{2011}}{2012}\cdot \dfrac{t^{2011}+\cdots+t^{2011-i}s^i+\cdots+s^{2011}}{2012}=1$
Now, applying the AM-GM inequality to the first factor, we have
$\dfrac{r^{2011}+\cdots+r^{2011-i}u^i+\cdots+u^{2011}}{2012}>\sqrt[2012]{(ru)^{\small\dfrac{2011\times 2012}{2}}}=(ru)^{\small{\dfrac{2011}{2}}}$
The inequality is strict, since equality holds only if all terms in the mean are equal to each other, which happpens only if $r=u$.
Similarly, we find
$\dfrac{t^{2011}+\cdots+t^{2011-i}s^i+\cdots+s^{2011}}{2012}>\sqrt[2012]{(ts)^{\small\dfrac{2011\times 2012}{2}}}=(ts)^{\small{\dfrac{2011}{2}}}$
Multiply both inequalities we obtain $(ru)^{\small{\dfrac{2011}{2}}}(ts)^{\small{\dfrac{2011}{2}}}<1$ which is equivalent to $rstu<1$, a contradiction.