Wikipedia
Virtual particles are often popularly described as coming in pairs, a particle and antiparticle, which can be of any kind. These pairs exist for an extremely short time, and mutually annihilate in short order. In some cases, however, it is possible to boost the pair apart using external energy so that they avoid annihilation and become real particles. This is one way of describing the process by which black holes evaporate.
The restriction to particle-antiparticle pairs is actually only necessary if the particles in question carry a conserved quantity, such as electric charge, which is not present in the initial or final state. Otherwise, other situations can arise. For instance, the beta decay of a neutron can happen through the emission of a single virtual, negatively charged W particle that almost immediately decays into a real electron and antineutrino; the neutron turns into a proton when it emits the W particle. The evaporation of a black hole is a process dominated by photons, which are their own antiparticles and are uncharged.
Noted scientists, such as Stephen Hawking, have postulated that radiation emitting from black holes are the likely result of particle pairs where one has fallen into the event horizon of the black hole. The other, without a pair to annihilate it, travels away in the form of emitting radiation.