Here comes COVID-19 version BA.2, BA.4, BA.5,...

[expontum]

Popular article referring to the BA.2 variant:Popular article: (many words, little data)
https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html

Preprint article referring to the BA.2 variant:Preprint article: (At 52 pages, too many words!)
https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf

[edited 1hr. after posting: Added preprint Abstract]
Cheers,
Tom

Sending over this COVID resource in case it's helpful in your research or daily work: Expontum (https://www.expontum.com/) - Helps students and researchers quickly find knowledge gaps and identify what research projects have been completed before. https://www.expontum.com/knowledgegaps.php?subj=COVID-19

 

[Point Conception]

I am unvaccinated for SARS-CoV-2 and don't have antibodies, rapid test today. Sure I've been exposed many times like in this wet market. So my T cells are most likely preventing infection (seroconvrsion/antibodies) Maybe it's best now to stop running scared and upgrade your physical health, my BMI. Is 21. Correct me if I'm wrong: My understanding is that T - cells can target non mutating viral proteins and up to 30 antigen epitopes -

 

[dlgoff]

Got my new updated COVID booster yesterday.

Feel horrrrrible today! Like a truck ran over me and I have zero energy left to even move. Gosh - this fatigue is major (even beyond or equal to my worst days with diabetic fatigue). Massive headache, chills, and tiredness.
Literally could not concentrate on any work and called it a day. It'd take me extended time to even do basic arithmetic today. . . . .let's see how long this lasts.

Good luck to all getting their boosters!

I just got my updated COVID booster a couple hours. Hope it doesn't make me feel horrible tomorrow.

 

[Astronuc]

I'll be getting Covid (SARS-Cov-2) booster, Influenza and RSV simultaneously. I'll report on any reaction.

Meanwhile - Men at greater risk of severe Covid - and now experts may know why
https://www.msn.com/en-us/health/me...ovid-and-now-experts-may-know-why/ar-AA1hG5w9

This is the conclusion of a team of researchers from University of Toronto, who conducted studies on mice into the role of the protein in cases of COVID-19.

They report that men only have one copy of the ACE2 gene - meaning that, when infected, too much of the protein is occupied by the virus and its protective role is compromised.

While the study has only been conducted in mice, it is likely the same mechanism is contributing to sex-based differences in Covid outcomes in humans as well.

Furthermore, the team proposes that synthetic ACE2 proteins might be given to people as protection in high Covid-risk situations, and as a therapy in hospitals.

See the PF thread on ACE-2 decoy.
https://www.physicsforums.com/threa...solution-to-covid-19-using-ace2-decoy.987905/

 

[dlgoff]

Hope it doesn't make me feel horrible tomorrow.

Just a bit of a sore triceps. Took a couple of Ibuprofen and all is okay.

 

[berkeman]

Just a bit of a sore triceps deltoid muscle.

Fixed that for you.

 

[dlgoff]

Fixed that for you.

Thank you sir.

 

[Astronuc]

Just a bit of a sore triceps. Took a couple of Ibuprofen and all is okay.

Just got my triple. No soreness.

I believe it is the deltoid anterior or clavicular part (pars clavicularis) in my case. I received RSV and Pfizer/BioNTech Covid in the left shoulder, and Influenza in the right shoulder. Now waiting for a reaction.

 

[berkeman]

I shot hoops after getting my flu vax yesterday in my left deltoid to try to help loosen it up, and it seems to have helped. Only a tiny soreness today. The bigger question is which deltoid should I get the COV booster in tomorrow... I think I'll go for the left one again and go shoot more hoops after...

 

[Astronuc]

I shot hoops after getting my flu vax yesterday in my left deltoid to try to help loosen it up, and it seems to have helped. Only a tiny soreness today. The bigger question is which deltoid should I get the COV booster in tomorrow... I think I'll go for the left one again and go shoot more hoops after...

I lifted weights - before and after. I can feel some irritation on my left side, but nothing on my right.

No fever, fatigue or discomfort, so far.

 

[dlgoff]

I think I'll go for the left one again ...

So, how's the arm?

 

[berkeman]

So, how's the arm?

It's okay. Deltoid muscle soreness from the 2nd shot was more than the flu vax a couple days ago, so I took a couple IB this morning and still shot hoops this afternoon. So far no side effects from the latest COV booster.

 

[kyphysics]

still shot hoops this afternoon. So far no side effects from the latest COV booster.

Off-topic: Are you any good at hoops? My favorite sport (to watch and play)!

 

[berkeman]

Off-topic: Are you any good at hoops? My favorite sport (to watch and play)!

Since it's OT, I'll respond via PM.

 

[kyphysics]

Anecdotally, the people I know getting Moderna's vax and boosters have had less symptoms/side-effects.

The was my experience "mostly." No symptoms/SE for the original Moderna vax. None for the 1st Moderna booster. Then, I took the Pfizer bivalent booster and got bad symptoms for a day or two. And the latest Moderna Spikevax booster did the same.

 

[berkeman]

Anecdotally, the people I know getting Moderna's vax and boosters have had less symptoms/side-effects.

Yeah, this latest booster a couple days ago was no problem at all. A bit of a sore deltoid (more than from the flu shot a couple days earlier -- weird), but no side effects at all. I've held off my usual high-intensity MTB rides the last couple of days to be cautious, but tomorrow I hit the single track!

 

[dlgoff]

My deltoid muscle is still sore from the Moderna Spikevax I had on October 3rd. Don't know if I going to get the second dose.

 

[berkeman]

My deltoid muscle is still sore from the Moderna Spikevax I had on October 3rd. Don't know if I going to get the second dose.

Was that your first vax for Covid? The booters now are single-dose.

 

[dlgoff]

Was that your first vax for Covid? The booters now are single-dose.

My COVD-19 Vaccination Record Card says "Reminder! Return for a second dose!"

 

[berkeman]

My COVD-19 Vaccination Record Card says "Reminder! Return for a second dose!"

Only if this was your first Covid vax ever...

 

[kyphysics]

CVS said they no longer record shots in a vax card anymore. The last one I got recorded was the Pfizer bivalent booster.

 

[dlgoff]

Only if this was your first Covid vax ever...

Well, I had the Moderna 1st and 2nd dose on 2/10/21 and 3/10/21, which they were aware of, and the Spikevac I had on 10/3 says it expires on 10/30/2023

 

[dlgoff]

CVS said they no longer record shots in a vax card anymore. The last one I got recorded was the Pfizer bivalent booster.

I didn't get mine at a CVS.

 

[kyphysics]

I didn't get mine at a CVS.

Yeah, I didn't mean to imply that you did. I was kind of just announcing it as a fact (for everyone to know) w/o any implications in mind.

Speaking of CVS, I see they are offering shingles, flu, hepatitis b, and pneumonia vaccines. I only got the COVID booster (dad has lung cancer + several other serious comorbidities, so I need to protect him).

I am going to sign up for flu this week, but never considered Hep B or Pneu in the past. Anyone else going to get these other ones?

 

[Sagittarius A-Star]

Took a couple of Ibuprofen

There exist studies, if administration of antipyretic analgesics has a negative effect on the antibody response. I found no such paper specifically related to mRNA vaccine.
Example:

The timing of administration of antipyretic analgesics appears to be paramount. In all studies that reported a negative effect on antibody response, the medications were given prophylactically. Interestingly, this effect was not seen when acetaminophen was given only four hours after immunization.6 Additionally, all reported decreases in antibody response occurred only with novel antigen vaccination, with little to no impact observed following booster immunizations.

Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027726/

 

[Astronuc]

I am going to sign up for flu this week, but never considered Hep B or Pneu in the past. Anyone else going to get these other ones?

I was thinking of the Pneu vaccine at some point. I could have added it to the cocktail, but I though 3 was enough (Covid booster, Influenza (for 65+), and RSV.

 

[kyphysics]

I was thinking of the Pneu vaccine at some point. I could have added it to the cocktail, but I though 3 was enough (Covid booster, Influenza (for 65+), and RSV.

I didn't get RSV yet either. I'm going to get 1 vax every 2 weeks. . .flu ---> RSV ---> tetanus (last one was 25+ years ago) ---> Hep B ---> Pneu.

Hopefully that catches me up with everything by December. I might combine a few, but just want to research to see it's okay (since I have some complicated diabetes).

 

[Sagittarius A-Star]

I was thinking of the Pneu vaccine at some point. I could have added it to the cocktail, but I though 3 was enough (Covid booster, Influenza (for 65+), and RSV.

In Germany, for 60+, vaccination against herpes zoster is officially recommended.
This is the case, since in 2018 an inactivated vaccine against it was released.

See also for USA:
https://www.cdc.gov/shingles/vaccination.html

 

[Astronuc]

In Germany, for 60+, vaccination against herpes zoster is officially recommended.
This is the case, since in 2018 an inactivated vaccine against it was released.

They actually gave me the option of adding the pneumococcal and Herpes zoster vaccines. I decided to defer. I thought 3 was enough in one event.

Herpes zoster, also known as shingles, is caused by reactivation of varicella-zoster virus (VZV), the same virus that causes varicella (chickenpox).

I had a varicella (chickenpox) infection in 1965. My brother got it first, so I was sent to stay with grandparents. He recovered, then I came down with it probably a week after I returned home.

I do plan to get the other vaccinations.

 

[dlgoff]

So far no side effects from the latest COV booster.

@berkeman
I got the SPIKEVAX on 10/3/23 and I got some heart pains. They are recommending a second shot but I'm not going to get it. See:
https://www.ema.europa.eu/en/news/c...link-very-rare-cases-myocarditis-pericarditis